Constitutive production of granulocyte/macrophage colony- stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes

Joshua A. Boyce; Daniel Friend; Michael F. Gurish

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Constitutive production of granulocyte/macrophage colony- stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes

机译：杂交嗜酸性粒细胞/嗜碱性粒细胞体外发育的低密度单核嗜酸性粒细胞组成性产生粒细胞/巨噬细胞集落刺激因子

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We recently described the development in vitro of cells with granules characteristic of eosinophils and basophils (hybrid granulocytes) from normal human cord blood mononuclear cells cultured for 14 days with recombi- nant human (rh) interleukin (IL)-3, rhIL-5, and a soluble basement membrane, Matrigel. Hybrid granulocytes consti- tutively produced granulocyte/macrophage colony-stimulat- ing factor (GM-CSF) and rapidly developed into eosinophils after the exogenous cytokines and Matrigel were removed.

机译：最近，我们描述了正常人脐带血单核细胞与重组人（rh）白细胞介素（IL）-3，rhIL-5，培养14天的嗜酸性粒细胞和嗜碱性粒细胞（杂交粒细胞）颗粒特征细胞的体外发育情况。以及可溶性基底膜Matrigel。杂种粒细胞持续产生粒细胞/巨噬细胞集落刺激因子（GM-CSF），并在去除外源细胞因子和基质胶后迅速发展为嗜酸性粒细胞。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第6期|p.2436-2441|共6页
作者
Joshua A. Boyce; Daniel Friend; Michael F. Gurish;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein. [J] . Sarmiento EU, Espiritu BR, Gleich GJ, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1995,第4期

机译：IL-3，IL-5和粒细胞巨噬细胞集落刺激因子可增强嗜酸性粒细胞主要碱性蛋白刺激的嗜碱性粒细胞介体释放。
2. IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein. [J] . E U Sarmiento, B R Espiritu, G J Gleich, The journal of immunology . 1995,第4期

机译：IL-3，IL-5和粒细胞巨噬细胞集落刺激因子可增强嗜酸性粒细胞主要碱性蛋白刺激的嗜碱性粒细胞介体释放。
3. Toll-like receptor-mediated eosinophil-basophil differentiation: Autocrine signalling by granulocyte-macrophage colony-stimulating factor in cord blood haematopoietic progenitors [J] . ReeceP., BaatjesA.J., CyrM.M., Immunology: An Official Journal of the British Society for Immunology . 2013,第2期

机译：Toll样受体介导的嗜酸性粒细胞-嗜碱性粒细胞分化：脐血造血祖细胞中粒细胞巨噬细胞集落刺激因子的自分泌信号传导
4. Conjugation of High-Molecular Weight Poly(ethylene glycol) to Cytokines: Granulocyte-Macrophage Colony-Stimulating Factors as Model Substrates [C] . Merry R.Sherman, L.David Williams, Mark G.P.Saifer, Poly(ethylene glycol) : Chemistry and biological applications . 1997

机译：高分子量聚乙二醇与细胞因子的缀合：粒细胞-巨噬细胞集落刺激因子作为模型基质。
5. Production and Bioactivity of Recombinant Human Granulocyte-Macrophage Colony- Stimulating Factor Using Chinese Hamster Ovary Cells [D] . Hamzeinejad, Sara. 2015

机译：使用中国仓鼠卵巢细胞的重组人粒细胞 - 巨噬细胞群刺激因子的生产和生物活性
6. Constitutive production of granulocyte/macrophage colony-stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes. [O] . J A Boyce, D Friend, M F Gurish, 1996

机译：由杂交嗜酸性粒细胞/嗜碱性粒细胞体外发育的低密度单核嗜酸性粒细胞组成性产生粒细胞/巨噬细胞集落刺激因子。
7. Constitutive production of granulocyte/macrophage colony-stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes. [O] . Boyce, J A, Friend, D, Gurish, M F, 1996

机译：由杂交嗜酸性粒细胞/嗜碱性粒细胞体外发育的低密度单核嗜酸性粒细胞组成性产生粒细胞/巨噬细胞集落刺激因子。

Constitutive production of granulocyte/macrophage colony- stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes

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