Identification of pentosidine as a native structure for advanced glycation end products in β_2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis

Toshio Miyata; Shinji Taneda; Ryuko Kawai

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Identification of pentosidine as a native structure for advanced glycation end products in β_2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis

机译：戊糖苷为透析相关淀粉样变性患者含β_2-微球蛋白的淀粉样原纤维中晚期糖基化终产物的天然结构的鉴定

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β_2-Microglobulin (β_2m) is a major constit- uent of amyloid fibrils in patients with dialysis-related amy- loidosis (DRA). Recently, we found that the pigmented and fluorescent adducts formed nonenzymatically between sugar and protein, known as advanced glycation end products (AGEs), were present inβ_2m-containing amyloid fibrils, suggesting the possible involvement of AGE-modifiedβ_2m in bone and joint destruction in DRA.

机译：β_2-微球蛋白（β_2m）是透析相关淀粉样变性病（DRA）患者的淀粉样蛋白原纤维的主要成分。最近，我们发现含β_2m的淀粉样原纤维中存在糖和蛋白质之间非酶促形成的色素加荧光加合物，称为高级糖基化终产物（AGEs），这表明AGE修饰的β_2m可能参与了DRA的骨骼和关节破坏。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第6期|p.2353-2358|共6页
作者
Toshio Miyata; Shinji Taneda; Ryuko Kawai;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Amyloid |[beta]|2-microglobulin is modified with imidazolone, a novel advanced glycation end product, in dialysis-related amyloidosis [J] . Toshimitsu Niwa, Tomoyuki Katsuzaki, Shigeru Miyazaki, Kidney international. . 1997,第1期

机译：在透析相关的淀粉样变性病中，用新型先进的糖基化终产物咪唑啉酮修饰了淀粉样蛋白|β| 2-微球蛋白
2. Amyloid |[beta]|2-microglobulin is modified with imidazolone, a novel advanced glycation end product, in dialysis-related amyloidosis [J] . Toshimitsu Niwa, Tomoyuki Katsuzaki, Shigeru Miyazaki, Kidney international. . 1997,第1期

机译：在透析相关的淀粉样变性病中，用新型先进的糖基化终产物咪唑啉酮修饰了淀粉样蛋白|β| 2-微球蛋白
3. Advanced glycation end product-modified beta2-microglobulin is a component of amyloid fibrils of primary localized cutaneous nodular amyloidosis. [J] . Fujimoto Norihiro, Yajima Mayumi, Ohnishi Yoshihiro, The Journal of investigative dermatology. . 2002,第3期

机译：晚期糖基化终产物修饰的β2-微球蛋白是原发性局部皮肤结节性淀粉样变性病的淀粉样蛋白原纤维的组成部分。
4. ADVANCED GLYCATION END PRODUCTS AND ADVANCED OXIDATION PROTEIN PRODUCTION IN PATIENTS WITH AA AMYLOIDOSIS [C] . R.Rysava, M.Kalousova, T.Zima, International Symposium on Amyloidosis . 2005

机译：AA淀粉样型患者的先进糖化末端产品和晚期氧化蛋白质产生
5. Influence of Four Differently Processed Diets on Plasma Levels of Advanced Glycation End Products (Ages), Serum Levels of Receptor for Advanced Glycation End Products (Rage), Serum and Urine Metabolome, and Fecal Microbiome in Healthy Dogs [D] . ?Bridglalsingh, Siobhan 2020

机译：四种不同加工饮食对晚期糖糖末端产物（年龄），晚期糖糖末端产物（RAGE），血清和尿液代谢的血清受体水平的影响，以及健康犬的粪便微生物组
6. Identification of pentosidine as a native structure for advanced glycation end products in beta-2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis. [O] . T Miyata, S Taneda, R Kawai, 1996

机译：戊糖苷被鉴定为透析相关淀粉样变性患者含β-2-微球蛋白的淀粉样原纤维中晚期糖基化终产物的天然结构。
7. Identification of pentosidine as a native structure for advanced glycation end products in beta-2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis. [O] . Miyata, T, Taneda, S, Kawai, R, 1996

机译：戊糖苷被鉴定为透析相关淀粉样变性患者含β-2-微球蛋白的淀粉样原纤维中晚期糖基化终产物的天然结构。

Identification of pentosidine as a native structure for advanced glycation end products in β_2-microglobulin-containing amyloid fibrils in patients with dialysis-related amyloidosis

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