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Checkpoints in the progression of autoimmune disease: Lessons from diabetes models

机译:自身免疫性疾病进展中的检查点:糖尿病模型的教训

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摘要

In the last few years, data from experiments employing trans- genic models of autoimmune diseases have strengthened a particular concept of autoimmunity: disease results not so much from cracks in tolerance induction systems, leading to the generation of an anti-self repertoire, as from the break- down of secondary systems that keep these cells in check.
机译:在过去的几年中,采用自身免疫性疾病转基因模型的实验数据加强了自身免疫性的特定概念:疾病的产生并不是由于耐受性诱导系统的破裂,而是导致产生了反自我库二级系统的故障使这些单元处于受控状态。

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