A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: A tale of smart bombs and the infantry

Lawrence Steinman

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A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: A tale of smart bombs and the infantry

机译：自身免疫浸润中的一些自身反应性细胞控制着大量非特异性细胞：关于智能炸弹和步兵的故事

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Inflammatory infiltrates in tissue-specific autoimmune disease com- prise a collection of T cells with specificity for an antigen in the target organ. These specific cells recruit a population of non- specific T cells and macrophages. The rare tissue-specific T cells in the infiltrate have the capacity to regulate both the influx and the efflux of cells from the tissue. Administration of an altered pep- tide ligand for the specific T cell which triggers autoimmunity can lead to the regression of the entire inflammatory en- semble in a few hours. Interleukin 4 is a critical cytokine involved in the regres- sion of the inflammatory infiltrate.

机译：组织特异性自身免疫性疾病中的炎性浸润包括对靶器官中的抗原具有特异性的T细胞集合。这些特异性细胞募集一群非特异性T细胞和巨噬细胞。浸润液中稀有的组织特异性T细胞具有调节细胞从组织中流入和流出的能力。对触发自身免疫的特定T细胞施用改变的肽配体可导致整个炎症集合在数小时内消退。白细胞介素4是参与炎性浸润表达的关键细胞因子。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第6期|p.2253-2256|共4页
作者
Lawrence Steinman;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Quantitative Proteome Profiling of CNS-Infiltrating Autoreactive CD4~+ Cells Reveals Selective Changes during Experimental Autoimmune Encephalomyelitis [J] . Michelle E. Turvey, Tomas Koudelka, Iain Comerford, Journal of proteome research . 2014,第8期

机译：中枢神经系统浸润的自身反应性CD4〜+细胞的蛋白质组定量分析揭示了实验性自身免疫性脑脊髓炎期间的选择性变化
2. I{kappa}B Kinase 2/beta Deficiency Controls Expansion of Autoreactive T Cells and Suppresses Experimental Autoimmune Encephalomyelitis. [J] . Greve B, Weissert R, Hamdi N, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2007,第1期

机译：I {kappa} B激酶2 /β缺乏控制自身反应性T细胞的扩增并抑制实验性自身免疫性脑脊髓炎。
3. I{kappa}B Kinase 2/beta Deficiency Controls Expansion of Autoreactive T Cells and Suppresses Experimental Autoimmune Encephalomyelitis. [J] . Greve B, Weissert R, Hamdi N, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2007,第1期

机译：I {kappa} B激酶2 /β缺乏控制自身反应性T细胞的扩增并抑制实验性自身免疫性脑脊髓炎。
4. Autoreactive T cells: any evidence in autoimmune liver disease? [C] . Y. MA, M. S. LONGHI, D. P. BOGDANOS, Falk Symposium . 2005

机译：自身反应性T细胞：自身免疫性肝病中的任何证据？
5. Activation of RNA-specific autoreactive B cells during B cell development on a normal and an autoimmune genetic background [D] . Han, Jin-Hwan 2009

机译：在正常和自身免疫遗传背景下B细胞发育过程中RNA特异性自身反应性B细胞的活化
6. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry. [O] . L Steinman 1996

机译：自身免疫浸润中的一些自身反应性细胞控制着大量非特异性细胞：关于智能炸弹和步兵的故事。
7. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry. [O] . Steinman, L 1996

机译：自身免疫浸润中的一些自身反应性细胞控制着大量非特异性细胞：关于智能炸弹和步兵的故事。

A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: A tale of smart bombs and the infantry

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