Ligand occupancy of the αVβ3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor I

John I. Jones; Tracy Prevette; Amy Gockerman

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Ligand occupancy of the αVβ3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor I

机译：αVβ3整联蛋白的配体占据是平滑肌细胞响应胰岛素样生长因子I迁移所必需的

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Smooth muscle cells (SMCs) have been shown to migrate in response to insulin-like growth factor I (IGF-I). However, the mechanism mediating this response has not been determined. The migration rates of porcine and human vascular SMCs were assessed in a monolayer wound- ing assay. IGF-I and IGF-II induced increases of 141/100 and 97/100, respectively, in the number of cells that migrated in 4 days. The presence of 0.2/100 fetal bovine serum in the culture medium was necessary for the IGFs to stimulate migration over uncoated plastic surfaces.

机译：平滑肌细胞（SMC）已显示出对胰岛素样生长因子I（IGF-1）的响应而迁移。但是，尚未确定介导该响应的机制。猪和人血管SMC的迁移率通过单层伤口测定进行评估。在4天内迁移的细胞数量中，IGF-I和IGF-II分别诱导增加141/100和97/100。培养基中存在0.2 / 100胎牛血清对于IGF刺激在未涂覆的塑料表面上的迁移是必需的。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第6期|p.2482-2487|共6页
作者
John I. Jones; Tracy Prevette; Amy Gockerman;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Blocking ligand occupancy of the αVβ3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells [J] . Bo Zheng, David R. Clemmons Proceedings of the National Academy of Sciences of the United States of America . 1998,第19期

机译：阻断αVβ3整联蛋白的配体占据可抑制血管平滑肌细胞中的胰岛素样生长因子I信号转导
2. The association between integrin-associated protein and SHPS-1 regulates insulin-like growth factor-I receptor signaling in vascular smooth muscle cells [J] . Maile LA., Badley-Clarke J., Clemmons DR. Molecular biology of the cell . 2003,第9期

机译：整合素相关蛋白和SHPS-1之间的关联调节血管平滑肌细胞中的胰岛素样生长因子-I受体信号传导
3. Glucose-oxidized low-density lipoproteins enhance insulin-like growth factor I-stimulated smooth muscle cell proliferation by inhibiting integrin-associated protein cleavage. [J] . Allen LB, Capps BE, Miller EC, Endocrinology . 2009,第3期

机译：葡萄糖氧化的低密度脂蛋白通过抑制整合素相关的蛋白裂解，增强了胰岛素样生长因子I刺激的平滑肌细胞增殖。
4. Val-Ala-Pro-Gly, An Elastin Derived Non-Integrin Ligand: Smooth Muscle Cell Adhesion and Specificity [C] . Andrea Gobin, Jennifer West Annual meeting of the Society For Biomaterials . 2003

机译：Val-Ala-Pro-Gly，一种弹性蛋白衍生的非整联蛋白配体：平滑肌细胞粘附性和特异性
5. Laminin-5 mediates vascular smooth muscle cell response to growth factors. [D] . Kingsley, Karl. 2001

机译：层粘连蛋白5介导血管平滑肌细胞对生长因子的反应。
6. Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor. [O] . J I Jones, T Prevette, A Gockerman, 1996

机译：α-V-β3整联蛋白的配体占据是平滑肌细胞响应胰岛素样生长因子迁移所必需的。
7. Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor. [O] . Jones, J I, Prevette, T, Gockerman, A, 1996

机译：α-V-β3整联蛋白的配体占据是平滑肌细胞响应胰岛素样生长因子迁移所必需的。

Ligand occupancy of the αVβ3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor I

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