Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells

Max Gassmann; Joachim Fandrey; Sandrine Bichet

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Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells

机译：分化胚胎干细胞的供氧和氧依赖基因表达

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Blastocyst-derived pluripotent mouse em- bryonic stem cells can differentiate in vitro to form so-called embryoid bodies (EBs), which recapitulate several aspects of murine embryogenesis. We used this in vitro model to study oxygen supply and consumption as well as the response to reduced oxygenation during the earliest stages of develop- ment. EBs were found to grow equally well when cultured at 20/100 (normoxia) or 1/100 (hypoxia) oxygen during the first 5 days of differentiation.

机译：囊胚来源的多能小鼠胚胎干细胞可以在体外分化形成所谓的胚状体（EBs），概括了鼠胚发生的几个方面。我们使用这种体外模型研究氧气的供应和消耗，以及在发育的最早阶段对减少氧合作用的反应。发现在分化的前5天中，在20/100（常氧）或1/100（低氧）的氧气下培养时，EB的生长同样良好。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.2867-2872|共6页
作者
Max Gassmann; Joachim Fandrey; Sandrine Bichet;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. Analysis of gene expressions of embryonic stem-derived Pdx1-expressing cells: implications of genes involved in pancreas differentiation [J] . Yoshida T, Murata K, Shiraki N, Development Growth and Differentiation . 2009,第4期

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4. EFFECT OF OXYGEN TENSION ON THE PROLIFERATION AND THE DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS [C] . M. Kimura, H. Kurosawa, Y. Amano Annual Meeting of the Japanese Association for Animal Cell Technology . 2006

机译：氧气张力对小鼠胚胎干细胞增殖和分化的影响
5. Multiple layers of gene expression regulation during murine embryonic stem cell differentiation induced by Nanog down regulation. [D] . Lu, Rong. 2007

机译：Nanog下调诱导的小鼠胚胎干细胞分化过程中的多层基因表达调控。
6. Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells. [O] . M Gassmann, J Fandrey, S Bichet, 1996

机译：分化胚胎干细胞中的氧供应和氧依赖性基因表达。
7. Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells. [O] . Gassmann, M, Fandrey, J, Bichet, S, 1996

机译：分化胚胎干细胞中的氧供应和氧依赖性基因表达。

Oxygen supply and oxygen-dependent gene expression in differentiating embryonic stem cells

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