Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2

Kumaravel Somasundaram; Gopalswamy Jayaraman; Trevor Williams

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Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2

机译：E1A抑制基质金属蛋白酶基因与其结合细胞类型特异性转录因子AP-2的能力有关

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Adenovirus E1A 243-amino acid protein can repress a variety of enhancer-linked viral and cellular pro- moters. This repression is presumed to be mediated by its interaction with and sequestration of p300, a transcriptional coactivator. Type IV 72-kDa collagenase is one of the matrix metalloproteases that has been implicated in differentiation, development, angiogenesis, and tumor metastasis.

机译：腺病毒E1A 243氨基酸蛋白可抑制多种与增强子相连的病毒和细胞启动子。推测这种抑制作用是由其与转录共激活因子p300的相互作用和螯合介导的。 IV型72 kDa胶原酶是基质金属蛋白酶之一，已与分化，发育，血管生成和肿瘤转移有关。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.3088-3093|共6页
作者
Kumaravel Somasundaram; Gopalswamy Jayaraman; Trevor Williams;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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5. Cell autonomous and non-cell autonomous requirements for transcription factor AP-2 in optic cup morphogenesis and development of the neural retina [D] . Bassett, Erin 2010

机译：视杯形态发生和神经视网膜发育中转录因子AP-2的细胞自主和非细胞自主要求
6. Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2. [O] . K Somasundaram, G Jayaraman, T Williams, 1996

机译：E1A抑制基质金属蛋白酶基因与其结合细胞类型特异性转录因子AP-2的能力有关。
7. Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2. [O] . Somasundaram, K, Jayaraman, G, Williams, T, 1996

机译：E1A抑制基质金属蛋白酶基因与其结合细胞类型特异性转录因子AP-2的能力有关。

Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2

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