Developmental abnormalities in cultured mouse embryos deprived of retinoic acid by inhibition of yolk-sac retinol binding protein synthesis

Claes Bavik; Simon J. Ward; Pierre Chambon

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Developmental abnormalities in cultured mouse embryos deprived of retinoic acid by inhibition of yolk-sac retinol binding protein synthesis

机译：通过抑制卵黄囊视黄醇结合蛋白合成，剥夺了视黄酸的小鼠胚胎发育异常

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Presomitic and 3- to 12-somite pair cultured mouse embryos were deprived of retinoic acid (RA) by yolk-sac injections of antisense oligodeoxynucleotides for retinol bind- ing protein (RBP). Inhibition of yolk-sac RBP synthesis was verified by immunohistochemistry, and the loss of activity of a lacZ-coupled RA-sensitive promoter demonstrated that embryos rapidly became RA-deficient.

机译：通过卵黄囊注射视黄醇结合蛋白（RBP）的反义寡聚脱氧核苷酸，剥夺了成对的和3至12至12个成对的小鼠胚胎的视黄酸（RA）。卵黄囊RBP合成的抑制作用已通过免疫组织化学验证，并且lacZ偶联的RA敏感启动子的活性丧失表明胚胎迅速变为RA缺陷型。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.3110-3114|共5页
作者
Claes Bavik; Simon J. Ward; Pierre Chambon;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Expression of retinol-binding protein messenger RNA and retinoic acid receptors in preattachment bovine embryos. [J] . Mohan M, Malayer JR, Geisert RD, Molecular reproduction and development . 2001,第3期

机译：视黄醇结合蛋白信使RNA和视黄酸受体在附着前牛胚胎中的表达。
2. Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. [J] . Kang S, Duell EA, Fisher GJ, The Journal of investigative dermatology. . 1995,第4期

机译：在体内将视黄醇应用于人皮肤可引起表皮增生和视黄酸特有的细胞类视黄醇结合蛋白，但没有可测量的视黄酸水平或刺激性。
3. Mouse retinol binding protein gene: cloning, expression and regulation by retinoic acid. [J] . Jessen KA, Satre MA Molecular and Cellular Biochemistry: An International Journal for Chemical Biology . 2000,第1a2期

机译：小鼠视黄醇结合蛋白基因：视黄酸的克隆，表达和调控。
4. Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells Requires Retinoic Acid and Bone Morphogenetic Protein Type IB Signaling [C] . D.C. WAN, Y.Y. SHI, R.P. NACAMULI, International Society of Craniofacial Surgery . 2007

机译：小鼠脂肪衍生的基质细胞的成骨分化需要视黄酸和骨形态发生蛋白类型IB信号传导
5. Retinoic acid transfer and protein-protein interaction between the cellular retinoic acid binding protein and the retinoic acid receptor probed by hydrogen deuterium exchange mass spectrometry. [D] . Sjoelund, Virginie. 2009

机译：氢氘交换质谱法检测细胞视黄酸结合蛋白与视黄酸受体之间的视黄酸转移和蛋白相互作用。
6. Developmental abnormalities in cultured mouse embryos deprived of retinoic by inhibition of yolk-sac retinol binding protein synthesis. [O] . C Båvik, S J Ward, P Chambon 1996

机译：通过抑制卵黄囊视黄醇结合蛋白合成剥夺了视黄酸的小鼠胚胎发育异常。
7. Developmental abnormalities in cultured mouse embryos deprived of retinoic by inhibition of yolk-sac retinol binding protein synthesis. [O] . Båvik, C, Ward, S J, Chambon, P 1996

机译：通过抑制卵黄囊视黄醇结合蛋白合成，剥夺了视黄酸的小鼠胚胎发育异常。

Developmental abnormalities in cultured mouse embryos deprived of retinoic acid by inhibition of yolk-sac retinol binding protein synthesis

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