Occurrence of poly(α2,8-deaminoneuraminic acid) in mammalian tissues: Widespread and developmentally regulated but highly selective expression on glycoproteins

Martin Ziak; Baoxi Qu; Xulei Zuo

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Occurrence of poly(α2,8-deaminoneuraminic acid) in mammalian tissues: Widespread and developmentally regulated but highly selective expression on glycoproteins

机译：哺乳动物组织中聚（α2,8-脱氨基神经氨酸）的发生：糖蛋白的广泛表达和发育调控但高度选择性表达

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In tissues of higher organisms homopoly- mers of α2,8-linked N-acetylneuraminic acid can be found as a posttranslational modification on selected proteins. We report here the discovery of homopolymers of 2,8-linked deaminoneuraminic acid [poly(2,8-KDN)] in various tissues derived from all three germ layers in vertebrates including mammals. The monoclonal antibody kdn8kdn in conjunction with a bacterial KDNase permitted the detection of poly(2,8- KDN) by immunohistochemistry and immunoblotting.

机译：在高等生物的组织中，可以发现α2,8连接的N-乙酰神经氨酸的同聚物是所选蛋白质的翻译后修饰。我们在这里报告2,8-连接的脱氨基神经氨酸[poly（2,8-KDN）]的均聚物在衍生自包括哺乳动物在内的脊椎动物的所有三个胚层的各种组织中的发现。单克隆抗体kdn8kdn与细菌KDNase结合可以通过免疫组织化学和免疫印迹检测到poly（2,8- KDN）。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.2759-2763|共5页
作者
Martin Ziak; Baoxi Qu; Xulei Zuo;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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专利

1. Poly(α2,8-deaminoneuraminic acid) is expressed in lung on a single 150-kDa glycoprotein and is an oncodevelopmental antigen [J] . BAOXI QU, MARTIN ZIAK, CHRISTIAN ZUBER, Proceedings of the National Academy of Sciences of the United States of America . 1996,第17期

机译：聚（α2,8-脱氨基神经氨酸）在单个150kDa糖蛋白上在肺中表达，是一种肿瘤发育抗原
2. Poly(α2,8-deaminoneuraminic acid) is expressed in lung on a single 150-kDa glycoprotein and is an oncodevelopmental antigen [J] . Baoxi Qu, Martin Ziak, Christian Zuber Proceedings of the National Academy of Sciences of the United States of America . 1996,第17期

机译：聚（α2,8-脱氨基神经氨酸）在单个150kDa糖蛋白上在肺中表达，是一种肿瘤发育抗原
3. Identification of megalin as the sole rat kidney sialoglycoprotein containing poly alpha2,8 deaminoneuraminic acid. [J] . Ziak M, Kerjaschki D, Farquhar MG, Journal of the American Society of Nephrology: JASN . 1999,第2期

机译：巨蛋白鉴定为唯一的含有聚α2,8脱氨基神经氨酸的大鼠肾脏唾液糖蛋白。
4. A regulatable selective system facilitating isolation of hih expression mammalian cells [C] . Kiichiro Teruya, Ying-Pei Zhang, Yoshinori Katakura Annual Meeting of the European Society of Animal Cell Technology . 1999

机译：一种可调节的选择性系统，促进HiH表达哺乳动物细胞的分离
5. Occurrence of poly(alpha28-deaminoneuraminic acid) in mammalian tissues: widespread and developmentally regulated but highly selective expression on glycoproteins. [O] . M Ziak, B Qu, X Zuo, 1996

机译：在哺乳动物组织中发生聚（α28-脱氨基神经氨酸）：在糖蛋白上广泛且受发育调节但选择性高。
6. Occurrence of poly(alpha2,8-deaminoneuraminic acid) in mammalian tissues: widespread and developmentally regulated but highly selective expression on glycoproteins. [O] . Ziak, M, Qu, B, Zuo, X, 1996

机译：在哺乳动物组织中发生聚（α2,8-脱氨基神经氨酸）：在糖蛋白上广泛且受发育调节，但选择性高。

Occurrence of poly(α2,8-deaminoneuraminic acid) in mammalian tissues: Widespread and developmentally regulated but highly selective expression on glycoproteins

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