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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Isolation of a Pax-6 homolog from the ribbonworm Lineus sanguineus
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Isolation of a Pax-6 homolog from the ribbonworm Lineus sanguineus

机译:从the虫线虫中分离出Pax-6同源物

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摘要

The Pax-6 genes of vertebrates and Drosoph- ila encode transcription factors with highly conserved paired- and homeodomains. They are expressed in the nervous system and the developing eyes. Loss-of-function mutations in mam- mals and flies lead to a reduction or absence of the eyes. By ectopic expression of Pax-6 in Drosophila ectopic eyes can be induced, indicating a determinative role in eye morphogenesis. We have isolated a Pax-6 homolog of the ribbonworm Lineus sanguineus.
机译:脊椎动物和果蝇的Pax-6基因编码具有高度保守的配对和同源域的转录因子。它们在神经系统和正在发育的眼睛中表达。哺乳动物和果蝇的功能丧失突变会导致眼睛减少或缺失。通过在果蝇异位眼中Pax-6的异位表达可以诱导,表明在眼形态发生中起决定性作用。我们已经分离了the虫线虫血红蛋白的Pax-6同源物。

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