Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57~KIP2, on chromosome 11p15

Shuhei Matsuoka; Jeffrey S. Thompson; Michael C. Edwards

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Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57~KIP2, on chromosome 11p15

机译：编码人类细胞周期蛋白依赖性激酶抑制剂p57〜KIP2的基因在11p15染色体上的印记

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Parental origin-specific alterations of chro- mosome 11p15 in human cancer suggest the involvement of one or more maternally expressed imprinted genes involved in embryonal tumor suppression and the cancer-predisposing Beckwith-Wiedemann syndrome (BWS). The gene encoding cyclin-dependent kinase inhibitor p57~KIP2, whose overexpres- sion causes G_1 phase arrest, was recently cloned and mapped to this band.

机译：父母对人染色体11p15的起源特异性改变表明，一种或多种母体表达的印迹基因参与了胚胎肿瘤的抑制以及易患癌症的贝克威斯-韦德曼综合征（BWS）。最近克隆了编码细胞周期蛋白依赖性激酶抑制剂p57〜KIP2的基因，该基因的过度表达引起G_1期阻滞，并定位到该条带上。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第7期|p.3026-3030|共5页
作者
Shuhei Matsuoka; Jeffrey S. Thompson; Michael C. Edwards;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Transcriptional upregulation of p57 (Kip2) by the cyclin-dependent kinase inhibitor BMS-387032 is E2F dependent and serves as a negative feedback loop limiting cytotoxicity [J] . Y Ma, W D Cress Oncogene . 2007,第24期

机译：细胞周期蛋白依赖性激酶抑制剂BMS-387032对p57（Kip2）的转录上调是E2F依赖性的，并且作为限制细胞毒性的负反馈回路
2. Periodic expression of the cyclin-dependent kinase inhibitor p57(Kip2) in trophoblast giant cells defines a G2-like gap phase of the endocycle [J] . Hattori N., Anson-Cartwright L., Cross JC., Molecular biology of the cell . 2000,第3期

机译：细胞周期蛋白依赖性激酶抑制剂p57（Kip2）在滋养层巨细胞中的周期性表达定义了内循环的G2样缺口期
3. The multiple roles of the cyclin-dependent kinase inhibitory protein p57 KIP2 in cerebral cortical neurogenesis [J] . TuryA., Mairet-CoelloG., Dicicco-BloomE. Developmental neurobiology . 2012,第6期

机译：细胞周期蛋白依赖性激酶抑制蛋白p57 KIP2在大脑皮层神经发生中的多种作用
4. Hypoxia-Induced Proliferation Of Human Pulmonary Arterial Smooth Muscle Cells (Pasmc) Is Involved In The Suppression Of Cyclin-Dependent Kinase Inhibitors, P21, P27 And P53 [C] . T. Ishizaki, S. Mizuno, M. Kadowaki, NATO Advanced Research Workshop on Problems of High Altitude Medicine and Biology . 2007

机译：缺氧诱导的人肺动脉平滑肌细胞（PASMC）的增殖参与抑制细胞周期蛋白依赖性激酶抑制剂，P21，P27和P53
5. Regulation of the human cell division cycle by the p16(Ink4a) cyclin-dependent kinase inhibitor and cyclin E. [D] . Grimison, Bryn. 2001

机译：p16（Ink4a）细胞周期蛋白依赖性激酶抑制剂和细胞周期蛋白E对人类细胞分裂周期的调节。
6. Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor p57KIP2 on chromosome 11p15. [O] . S Matsuoka, J S Thompson, M C Edwards, 1996

机译：编码人类细胞周期蛋白依赖性激酶抑制剂p57KIP2的基因在11p15染色体上的印记。
7. The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer. [O] . Coley, HM, Safuwan, NA, Chivers, P, 2012

机译：细胞周期蛋白依赖性激酶抑制剂p57（Kip2）在卡铂抗性中受表观遗传调控，并导致对卵巢癌CDK抑制剂seliciclib的附带敏感性。

Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57~KIP2, on chromosome 11p15

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