Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex 're-presentation' of exogenous antigen by tumor-infiltrating antigen-presenting cells

Beth A. Pulaski; Kun-Yun Yeh; Nilabh Shastri

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Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex 're-presentation' of exogenous antigen by tumor-infiltrating antigen-presenting cells

机译：白细胞介素3通过肿瘤浸润性抗原呈递细胞增强细胞毒性T淋巴细胞的发育和I类主要组织相容性复合物“重新呈递”外源性抗原

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We show that interleukin 3 (IL-3) enhances the generation of tumor-specific cytotoxic T lymphocytes (CTLs) through the stimulation of host antigen-presenting cells (APCs). The BALB/c (H-2~d) spontaneous lung carcinoma line 1 was modified by gene transfection to express ovalbumin as a nom myeloid development.

机译：我们显示白介素3（IL-3）通过刺激宿主抗原呈递细胞（APC）增强了肿瘤特异性细胞毒性T淋巴细胞（CTL）的生成。通过基因转染修饰BALB / c（H-2〜d）自发性肺癌细胞系1，以表达卵清蛋白作为正常骨髓的发育。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第8期|p.3669-3674|共6页
作者
Beth A. Pulaski; Kun-Yun Yeh; Nilabh Shastri;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. The generation of antigen-specific, major histocompatibility complex-restricted cytotoxic T lymphocytes of the CD4+ phenotype. Enhancement by the cutaneous administration of interleukin 2. [J] . G E Hancock, Z A Cohn, G Kaplan The Journal of Experomental Medicine . 1989,第3期

机译：抗原特异性，主要组织相容性复合物限制的CD4 +表型细胞毒性T淋巴细胞的产生。皮肤给予白介素2的增强作用。
2. The generation of antigen-specific, major histocompatibility complex-restricted cytotoxic T lymphocytes of the CD4+ phenotype. Enhancement by the cutaneous administration of interleukin 2. [J] . G E Hancock, Z A Cohn, G Kaplan The Journal of Experomental Medicine . 1989,第3期

机译：抗原特异性，主要组织相容性复合物限制的CD4 +表型细胞毒性T淋巴细胞的产生。皮肤给予白介素2的增强作用。
3. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. [J] . R de Waal Malefyt, J Haanen, H Spits, The Journal of Experomental Medicine . 1991,第4期

机译：白介素10（IL-10）和病毒IL-10通过下调II类主要组织相容性复合物表达来降低单核细胞的抗原呈递能力，从而大大降低了抗原特异性人T细胞的增殖。
4. IN VIVO CYTOSOLIC DELIVERY OF EXOGENOUS ANTIGEN MEDIATED BY LISTERIOLYSIN O: ENHANCED CYTOTOXIC T-LYMPHOCYTE INDUCTION AND TUMOR PROTECTION [C] . M. Mandal, K.-D. Lee International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：脂溶素O介导的外源抗原的体内细胞液递送：增强的细胞毒性T淋巴细胞诱导和肿瘤保护
5. Increased density of class I major histocompatibility complex antigens and decreased density of T-cell differentiation antigens in the early stages of T-cell activation [D] . 松井良樹 1988

机译：在T细胞活化的早期，I类主要组织相容性复合抗原的密度增加，而T细胞分化抗原的密度降低
6. Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex re-presentation of exogenous antigen by tumor-infiltrating antigen-presenting cells. [O] . B A Pulaski, K Y Yeh, N Shastri, 1996

机译：白细胞介素3通过肿瘤浸润抗原呈递细胞增强细胞毒性T淋巴细胞的发育和外源性抗原的I类主要组织相容性复合物重新呈递。
7. Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex "re-presentation" of exogenous antigen by tumor-infiltrating antigen-presenting cells. [O] . Pulaski, B A, Yeh, K Y, Shastri, N, 1996

机译：白细胞介素3通过肿瘤浸润抗原呈递细胞增强细胞毒性T淋巴细胞的发育和外源性抗原的I类主要组织相容性复合物“重新呈递”。
8. Role of the Major Histocompatibility Complex in T Cell Activation of B Cell Subpopulations, Lyb-5(+) and Lyb-5(-) B Cell Subpopulations Differ in Their Requirement for Major Histocompatibility Complex-Restricted T Cell Recognition [R] . Singer, A., Morrissey, P. J., Hathcock, K. S., 1981

机译：主要组织相容性复合物在B细胞亚群，Lyb-5（+）和Lyb-5（ - ）B细胞亚群的T细胞活化中的作用不同于它们对主要组织相容性复杂限制性T细胞识别的要求

Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex 're-presentation' of exogenous antigen by tumor-infiltrating antigen-presenting cells

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