Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2

Hector Molina; V. Michael Holers; Bin Li

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Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2

机译：补体受体1和2不足的小鼠的体液免疫反应明显受损

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Complement receptor 1 (CR1, CD35) and complement receptor 2 (CR2, CD21) have been implicated as regulators of B-cell activation. We explored the role of these receptors in the development of humoral immunity by gener- ating CR1- and CR2-deficient mice using gene-targeting tech- niques. These mice have normal basal levels of IgM and of IgG isotypes. B- and T-cell development are overtly normal. Never- theless, B-cell responses to low and high doses of a T-cell- dependent antigen are impaired with decreased titers of antigen- specific IgM and IgG isotypes.

机译：补体受体1（CR1，CD35）和补体受体2（CR2，CD21）被认为是B细胞活化的调节剂。我们使用基因靶向技术通过产生CR1和CR2缺陷型小鼠，探索了这些受体在体液免疫发展中的作用。这些小鼠的IgM和IgG同种型的基础水平正常。 B细胞和T细胞发育明显正常。但是，B细胞对低剂量和高剂量T细胞依赖性抗原的反应会因抗原特异性IgM和IgG同种型的滴度降低而受损。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第8期|p.3357-3361|共5页
作者
Hector Molina; V. Michael Holers; Bin Li;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice. [J] . Twohig JP, Pappworth IY, Sivasankar B Molecular Immunology . 2009,第10期

机译：过早表达人补体受体2（CR2，CD21）的小鼠中的B细胞个体发育缺陷和体液免疫反应与衰老的野生型小鼠相似。
2. Cellular and humoral immune responses to heat shock protein 65 are both involved in promoting fatty-streak formation in LDL-receptor deficient mice. [J] . George J, Afek A, Gilburd B, Journal of the American College of Cardiology . 2001,第3期

机译：对热休克蛋白65的细胞和体液免疫反应均参与促进LDL受体缺陷小鼠的脂肪条纹形成。
3. T cell-independent and T cell-dependent immunoglobulin G responses to polyomavirus infection are impaired in complement receptor 2-deficient mice. [J] . Szomolanyi Tsuda E, Seedhom MO, Carroll MC, Virology . 2006,第1期

机译：在补体受体2缺陷小鼠中，T细胞非依赖性和T细胞非依赖性免疫球蛋白G对多瘤病毒感染的反应受到损害。
4. Toll-Like Receptor Deficient Mice Reveal How Innate Immune Signaling Influences Salmonella Virulence Strategies [C] . Kelsey Sivick-Gauthier, Nicholas Arpaia, Gabrielle L. Reiner, Molecular Medicine TRI-CON. . 2014

机译：Toll样受体缺乏小鼠揭示了天生的免疫信号如何影响沙门氏菌毒力策略
5. Human humoral immune responses to thymic-dependent antigens in severe combined immune deficient mice engrafted with human lymphocytes. [D] . Williams, Scott Seth. 1996

机译：在植入人淋巴细胞的严重组合免疫缺陷小鼠中，对胸腺依赖性抗原的人体液免疫反应。
6. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. [O] . H Molina, V M Holers, B Li, 1996

机译：补体受体1和2不足的小鼠的体液免疫反应明显受损。
7. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. [O] . Molina, H, Holers, V M, Li, B, 1996

机译：补体受体1和2不足的小鼠的体液免疫反应明显受损。

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2

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