The A subunit of DNA gyrase in Mycobacte- rium leprae, unlike its counterpart in Mycobacterium tubercu- losis, is produced by protein splicing as its gene, gyrA, harbors a 1260-bp in-frame insertion encoding an intein, a putative homing endonuclease. Analysis of the gyrA locus from differ- ent mycobacterial species revealed the presence of inteins in Mycobacterium flavescens, Mycobacterium gordonae, and Myco- bacterium kansasii but not in 10 other pathogenic or sapro- phytic mycobacteria.
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