Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility

David J. Dix; James W. Allen; Barbara W. Collins

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Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility

机译：Hsp70-2的靶向基因破坏导致减数分裂失败，生殖细胞凋亡和男性不育

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In addition to the five 70-kDa heat shock proteins (HSP70) common to germ cells and somatic tissues of mammals, spermatogenic cells synthesize HSP70-2 during meiosis. To determine if this unique stress protein has a critical role in meiosis, we used gene-targeting techniques to disrupt Hsp70-2 in mice. Male mice homozygous for the mutant allele (Hsp70-2~-/-) did not synthesize HSP70-2, lacked postmeiotic spermatids and mature sperm, and were infertile.

机译：除了哺乳动物生殖细胞和体细胞组织共有的五个70kDa热休克蛋白（HSP70）外，减数分裂过程中，生精细胞还合成HSP70-2。为了确定这种独特的应激蛋白是否在减数分裂中起关键作用，我们使用了基因靶向技术来破坏小鼠中的Hsp70-2。突变等位基因（Hsp70-2〜-/-）纯合的雄性小鼠不能合成HSP70-2，缺乏减数分裂后的精子和成熟精子，并且不育。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第8期|p.3264-3268|共5页
作者
David J. Dix; James W. Allen; Barbara W. Collins;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. Long-term exposure of xenoestrogens with environmental relevant concentrations disrupted spermatogenesis of zebrafish through altering sex hormone balance, stimulating germ cell proliferation, meiosis and enhancing apoptosis [J] . Wang Ya-Qin, Li Ying-Wen, Chen Qi-Liang, Environmental Pollution . 2019,第JANa期

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6. Targeted gene disruption of Hsp70-2 results in failed meiosis germ cell apoptosis and male infertility. [O] . D J Dix, J W Allen, B W Collins, 1996

机译：Hsp70-2的靶向基因破坏导致减数分裂失败生殖细胞凋亡和男性不育。
7. Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility. [O] . Dix, D J, Allen, J W, Collins, B W, 1996

机译：Hsp70-2的靶向基因破坏导致减数分裂失败，生殖细胞凋亡和男性不育。

Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility

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