cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes

Josef Bodor; Anna-Lena Spetz; Jack L. Strominger

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes

【24h】

cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes

机译：转录阻遏物ICER在发育中和成熟的人T淋巴细胞中的cAMP诱导性

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Stimulation of the cAMP-dependent signal- ing pathway exerts an inhibitory effect on the proliferation and effector functions of T cells. The ability of T cells to form high intracellular levels of cAMP is acquired during devel- opment in the human thymus and is retained by the majority of mature peripheral T lymphocytes. Here we show that elevated cAMP levels in T cells correlate with the expression of the potent transcriptional repressor ICER (inducible camp early repressor) previously described in the hypothalamic- pituitary-gonadal axis.

机译：刺激依赖cAMP的信号通路对T细胞的增殖和效应子功能产生抑制作用。 T细胞形成高细胞内cAMP的能力是在人胸腺发育过程中获得的，并被大多数成熟的外周T淋巴细胞所保留。在这里，我们显示T细胞中cAMP水平升高与先前在下丘脑-垂体-性腺轴中描述的有效转录阻遏物ICER（诱导型营地早期阻遏物）的表达相关。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第8期|p.3536-3541|共6页
作者
Josef Bodor; Anna-Lena Spetz; Jack L. Strominger;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Suppression of MIP-1?2 transcription in human T cells is regulated by inducible cAMP early repressor (ICER) [J] . James S. Foulke Jr., Josef Bodor, Marvin S. Reitz Jr., Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2006,第2期

机译：诱导型cAMP早期阻遏物（ICER）调节人T细胞中MIP-1？2转录的抑制
2. Repression of tax-mediated human t-lymphotropic virus type 1 transcription by inducible cAMP early repressor (ICER) protein in peripheral blood mononuclear cells. [J] . Newbound GC, ORourke JP, Collins ND, Journal of Medical Virology . 2000,第2期

机译：在外周血单核细胞中通过诱导性cAMP早期阻遏物（ICER）蛋白抑制税收介导的1型人t淋巴病毒的转录。
3. Inducible cAMP early repressor splice variants ICER I and IIgamma both repress transcription of c-fos and chromogranin A. [J] . Misund K, Steigedal TS, Laegreid A, Journal of cellular biochemistry. . 2007,第6期

机译：诱导型cAMP早期阻遏物剪接变体ICER I和IIgamma均抑制c-fos和嗜铬粒蛋白A的转录。
4. Genome-Wide Discovery of Modulators of Transcriptional Interactions in Human B Lymphocytes [C] . Kai Wang, Ilya Nemenman, Nilanjana Banerjee, Annual International Conference on Research in Computational Molecular Biology(RECOMB 2006); 20060402-05; Venice(IT) . 2006

机译：人类B淋巴细胞转录相互作用调控因子的全基因组发现
5. Expression and recombinase activity of RAG 1 and two splice variants of RAG 2 in mature human primary tonsilar B lymphocytes. [D] . Gillis, Lisa Jane. 1999

机译：RAG 1和RAG 2的两个剪接变体在成熟的人类扁桃体B淋巴细胞中的表达和重组酶活性。
6. cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes. [O] . J Bodor, A L Spetz, J L Strominger, 1996

机译：在发育中和成熟的人类T淋巴细胞中转录抑制子ICER的cAMP诱导性。
7. cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes. [O] . Bodor, J, Spetz, A L, Strominger, J L, 1996

机译：在发育中和成熟的人类T淋巴细胞中转录抑制子ICER的cAMP诱导性。
8. Activation of Mouse Lymphocytes by Anti-Immunoglobulin. II. A Thymus-Independent Response by a Mature Subset of B Lymphocytes [R] . Sieckmann, D. G., Scher, I., Asofsky, R., 1978

机译：抗免疫球蛋白激活小鼠淋巴细胞。 II。 B淋巴细胞成熟亚群的胸腺独立反应

cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes

摘要

著录项

相似文献

相关主题

期刊订阅