Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from G_i2α- / - mice

Uwe Rudolph; Karsten Spicher; Lutz Birnbaumer

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Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from G_i2α- / - mice

机译：G_i2α-/-小鼠组织和细胞中腺苷酸环化酶的抑制和G蛋白亚基表达的改变以及ADP-核糖基化模式的改变

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The inhibition of α_i2/ mouse cardiac isoproterenol-stimulated adenylyl cyclase (AC; EC 4.6.1.1) activity by carbachol and that of _i2/ adipocyte AC by phenylisopropyladenosine (PIA), prostaglandin E2, and nic- otinic acid were partially, but not completely, inhibited. While the inhibition of cardiac AC was affected in all _i2/ animals tested, only 50/100 of the _i2/ animals showed an impaired inhibition of adipocyte AC, indicative of a partial penetrance of this phenotype.

机译：苯异丙基腺苷（PIA），前列腺素E2和烟碱酸对α_i2/小鼠心脏异丙肾上腺素刺激的腺苷酸环化酶（AC; EC 4.6.1.1）的抑制作用和对_i2 /脂肪细胞AC的抑制作用部分但不是完全抑制。，被抑制。尽管在所有测试的_i2 /动物中心脏AC的抑制均受到影响，但只有/ 100i的_i2 /动物显示出对脂肪细胞AC的抑制作用减弱，表明该表型的部分渗透。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第8期|p.3209-3214|共6页
作者
Uwe Rudolph; Karsten Spicher; Lutz Birnbaumer;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. High level expression of transfected G protein αi3 subunit is required for plasma membrane targeting and adenylyl cyclase inhibition in NIH 3T3 fibroblasts [J] . de Mazancourt Philippe, Farquhar Marilyn Gist, Hermouet Sylvie, FEBS Letters . 1992,第2a3期

机译：NIH 3T3成纤维细胞中质膜靶向和腺苷酸环化酶抑制需要转染的G蛋白αi3亚基的高水平表达
2. Expression pattern of melanosomal proteins following inhibition of soluble adenylyl cyclase [J] . Wind O., Zhou D., Zippin J. H. The Journal of investigative dermatology. . 2018,第5a19期

机译：抑制可溶性腺苷酸环酶后黑色素蛋白的表达模式
3. Quantitative Proteomics Reveal an Altered Pattern of Protein Expression in Brain Tissue from Mice Lacking GPR37 and GPR37L1 [J] . Nguyen TrangKimberly Thu, Dammer Eric B., Owino Sharon A., Journal of proteome research . 2020,第2期

机译：定量蛋白质组学显示缺乏GPR37和GPR37L1的小鼠脑组织中蛋白质表达的改变模式。
4. Adenylyl Cyclase-Associated Protein 1 in Metastasis of Squamous Cell Carcinoma of the Head and Neck and Non-Small Cell Lung Cancer [C] . G. V. Kakurina, E. S. Kolegova, O. V. Cheremisina, International Conference on Physics of Cancer . 2016

机译：腺苷酸环酶相关蛋白1在头部和颈部和非小细胞肺癌的鳞状细胞癌转移中
5. Vesicle trafficking and protein synthesis, target adenylyl cyclase A to the back of migrating cells, localizing the release of chemoattractant to the trailing edge. [D] . Kriebel, Paul W. 2009

机译：囊泡运输和蛋白质合成，将腺苷酸环化酶A靶向到迁移细胞的后部，将趋化因子的释放定位在后缘。
6. Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-mice. [O] . U Rudolph, K Spicher, L Birnbaumer 1996

机译：腺苷酸环化酶抑制和改变的Gi2 alpha-/-小鼠的组织和细胞中G蛋白亚基的表达和ADP-核糖基化模式。
7. Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-mice. [O] . Rudolph, U, Spicher, K, Birnbaumer, L 1996

机译：腺苷酸环化酶抑制和改变的Gi2 alpha-/-小鼠的组织和细胞中G蛋白亚基的表达和ADP-核糖基化模式。
8. Cellular Regulation of ADP-Ribosylation of Proteins. 3. Selective Augmentation of In vitro ADP-Ribosylation of Histone H3 in Murine Thymic Cells after In vivo Emetine Treatment. [R] . Sooki-Toth, A., Banfalvi, G., Szoelloesi, J., 1989

机译：蛋白质aDp-核糖基化的细胞调节。 3.体内依美舒治疗后小鼠胸腺细胞中组蛋白H3的体外aDp-核糖基化的选择性增强。

Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from G_i2α- / - mice

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