Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH_2 peptide

Siow-Kee Kong; Moon Bin Yim; Earl R. Stadtman

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Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH_2 peptide

机译：过氧亚硝酸盐禁用酪氨酸磷酸化调节机制：淋巴细胞特异性酪氨酸激酶无法磷酸化硝化的cdc2（6-20）NH_2肽

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To determine if nitration of tyrosine residues by peroxynitrite (PN), which can be generated endogenously, can disrupt the phosphorylation of tyrosine residues in pro- teins involved in cell signaling networks, we studied the effect of PN-promoted nitration of tyrosine residues in a penta- decameric peptide, cdc2(6-20)NH_2, on the ability of the peptide to be phosphorylated. cdc2(6-20)NH_2 corresponds to the tyrosine phosphorylation site of p34~cdc2 kinase, which is phosphorylated by lck kinase (lymphocyte-specific tyrosine kinase, p56~lck).

机译：为了确定内源性过氧亚硝酸盐（PN）酪氨酸残基的硝化是否可以破坏细胞信号网络中涉及的蛋白质中酪氨酸残基的磷酸化，我们研究了PN促进酪氨酸残基硝化的作用。五聚体肽cdc2（6-20）NH_2，取决于该肽被磷酸化的能力。 cdc2（6-20）NH_2对应于p34〜cdc2激酶的酪氨酸磷酸化位点，该位点被lck激酶（淋巴细胞特异性酪氨酸激酶，p56〜lck）磷酸化。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第8期|p.3377-3382|共6页
作者
Siow-Kee Kong; Moon Bin Yim; Earl R. Stadtman;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Effects of Halogenation on Tyrosine Phosphorylation and Peptide Binding to the Src Homology 2 Domain of Lymphocyte-Specific Protein Tyrosine Kinase [J] . Toshimitsu Okamura, Tatsuya Kikuchi, Mika Nodaira, Biological & pharmaceutical bulletin . 2012,第3期

机译：卤代对酪氨酸磷酸化和肽与淋巴细胞特异性蛋白酪氨酸激酶src同源2域结合的影响。
2. Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides. [J] . T Kimura, H Sakamoto, E Appella, Molecular and Cellular Biology . 1996,第4期

机译：通过酪氨酸磷酸化或磷酸化免疫受体基于酪氨酸的活化基序肽的结合，在蛋白质酪氨酸激酶p72syk中诱导构象变化。
3. Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides. [J] . T Kimura, H Sakamoto, E Appella, Molecular and Cellular Biology . 1996,第4期

机译：通过酪氨酸磷酸化或磷酸化免疫受体基于酪氨酸的活化基序肽的结合，在蛋白质酪氨酸激酶p72syk中诱导构象变化。
4. Profiling and Cross-Talk of Tyrosine Phosphorylation with Lysine Acetylation and Succinylation in Tyrosine Kinase Inhibitor Resistant Breast Cancer Cells [C] . Hongbo Gu, Erik J. Soderblom, J. Will Thompson, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：酪氨酸激酶抑制剂抗性乳腺癌细胞赖氨酸乙酰化和琥珀酸抗蛋白酶磷酸化的分析和串扰
5. Revealing the mechanisms of peroxynitrite dependent tyrosine nitration in manganese superoxide dismutase and alpha-synuclein. [D] . Surmeli, Nur Basak. 2009

机译：揭示了锰超氧化物歧化酶和α-突触核蛋白中过亚硝酸盐依赖性酪氨酸硝化的机理。
6. Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide. [O] . S K Kong, M B Yim, E R Stadtman, 1996

机译：过氧亚硝酸盐禁用酪氨酸磷酸化调节机制：淋巴细胞特异性酪氨酸激酶无法磷酸化硝化的cdc2（6-20）NH2肽。
7. Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide. [O] . Kong, S K, Yim, M B, Stadtman, E R, 1996

机译：过氧亚硝酸盐禁用酪氨酸磷酸化调节机制：淋巴细胞特异性酪氨酸激酶无法磷酸化硝化的cdc2（6-20）NH2肽。
8. DMBA induces tyrosine phosphorylation of PLC-(gamma)1 and activates the tyrosine kinases lck and fyn in the HPB-ALL human T-cell line [R] . Archuleta, M M, Schieven, G L, Ledbetter, JA, 1993

机译：DmBa诱导pLC-（γ）1的酪氨酸磷酸化并激活HpB-aLL人T细胞系中的酪氨酸激酶lck和fyn。

Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH_2 peptide

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