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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The insect neuropeptide prothoracicotropic hormone is released with a daily rhythm: Re-evaluation of its role in development
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The insect neuropeptide prothoracicotropic hormone is released with a daily rhythm: Re-evaluation of its role in development

机译：昆虫神经肽促甲状腺激素以每日节律释放：重新评估其在发育中的作用

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摘要

Prothoracicotropic hormone (PTTH) is the central cerebral neurohormone in insect development. Its release has been believed for decades to be confined to one (or two) critical moments early in each developmental stage at which time it triggers prolonged activation of the prothoracic glands to synthesize and release the steroid molting hormones (ecdysteroids), which elicit developmental responses in target tissues. We used an in vitro assay for PTTH released from excised brains of the bug Rhodnius prolixus and report that release of PTTH does occur at the expected time on day 6, but that this release is merely the first in a daily rhythm of release that continues throughout most of the 21 days of larval-adult development.
机译：促前列腺激素（PTTH）是昆虫发育中的中枢神经激素。几十年来，人们一直认为它的释放被限制在每个发育阶段的早期（一或两个）关键时刻，在那一刻，它触发了前胸腺的长时间激活，以合成和释放甾类蜕皮激素（蜕皮类固醇），从而引发发育反应。在目标组织中。我们使用了一种体外测定方法，用于对从Rhodnius prolixus虫的切除大脑中释放的PTTH进行分析，并报告说PTTH的确在第6天的预期时间发生了释放，但是这种释放仅仅是整个释放过程中日常释放节奏中的第一个幼虫成虫发育的21天大部分时间。

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