Dominant-negative p53 mutations selected in yeast hit cancer hot spots

Rainer K. Brachmann; Marc Vidal; Jef D. Boeke

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Dominant-negative p53 mutations selected in yeast hit cancer hot spots

机译：在酵母命中的癌症热点中选择的显性阴性p53突变

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Clinically important mutant p53 proteins may be tumorigenic through a dominant-negative mechanism or due to a gain-of-function. Examples for both hypotheses have been described; however, it remains unclear to what extent they apply to TP53 mutations in general. Here it is shown that the mutational spectrum of dominant-negative p53 mutants selected in a novel yeast assay correlates tightly with p53 mutations in cancer.

机译：临床上重要的突变型p53蛋白可能通过显性阴性机制或由于获得功能而致瘤。已经描述了两种假设的例子；然而，目前尚不清楚它们在多大程度上适用于TP53突变。在此显示，在新型酵母分析中选择的显性阴性p53突变体的突变谱与癌症中的p53突变紧密相关。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第9期|p.4091-4095|共5页
作者
Rainer K. Brachmann; Marc Vidal; Jef D. Boeke;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. TP53 hot spot mutations in ovarian cancer: Selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas [J] . Seagle Brandon-Luke L., Yang Chia-Ping Huang, Eng Kevin H., Gynecologic Oncology: An International Journal . 2015,第1期

机译：卵巢癌中的TP53热点突变：体外对微管稳定剂的选择性耐药以及《癌症基因组图集》的不同生存结果
2. Hitting cancers' weak spots: vulnerabilities imposed by p53 mutation [J] . Gurpinar Evrim, Vousden Karen H. Trends in Cell Biology . 2015,第8期

机译：击中癌症的弱点：p53突变带来的脆弱性
3. Basic Science Ovarian Cancer Differential response to microtubule stabilizing agents of ovarian cancer cells harboring hot spot mutations of p53 [J] . Salinas Adrian, Hoffstetter Gerda, Yang Chia-Ping Huang, Gynecologic Oncology: An International Journal . 2015,第2期

机译：基础科学卵巢癌对具有p53热点突变的卵巢癌细胞微管稳定剂的差异反应
4. Correlation Analysis between PIK3CA, TP53, CDH1 Genes Mutations and Breast Cancer [C] . Dongyue Zhu, Yunjing Gu, Ping Zhu International Symposium on Distributed Computing and Applications for Business Engineering and Science . 2018

机译：PIK3CA，TP53，CDH1基因突变与乳腺癌的相关性分析
5. Determining the role of p53 mutation in human breast cancer progression using recombinant mutant/wild-type p53 heterozygous human mammary epithelial cell culture models. [D] . Junk, Damian Jerome. 2008

机译：使用重组突变体/野生型p53杂合性人类乳腺上皮细胞培养模型确定p53突变在人类乳腺癌进展中的作用。
6. Dominant-negative p53 mutations selected in yeast hit cancer hot spots. [O] . R K Brachmann, M Vidal, J D Boeke 1996

机译：在酵母中选择的显性阴性p53突变会击中癌症热点。
7. Dominant-negative p53 mutations selected in yeast hit cancer hot spots. [O] . Brachmann, R K, Vidal, M, Boeke, J D 1996

机译：在酵母中选择的显性阴性p53突变会击中癌症热点。
8. Development of Yeast as an In Vivo Test Tube to Characterize a Broad Spectrum of p53 Mutations Associated with Breast Cancer [R] . Resnick, M. A. , Inga, A. , Storici, F. , 2002

机译：开发酵母作为体内试管，以表征与乳腺癌相关的广谱p53突变

Dominant-negative p53 mutations selected in yeast hit cancer hot spots

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