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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Pax3 modulates expression of the c-Met receptor during limb muscle development
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Pax3 modulates expression of the c-Met receptor during limb muscle development

机译:Pax3调节肢体肌肉发育过程中c-Met受体的表达

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摘要

Pax3 is a transcription factor whose expres- sion has been used as a marker of myogenic precursor cells arising in the lateral somite destined to migrate to and populate the limb musculature. Accruing evidence indicates that the embryologic origins of axial and appendicular mus- cles are distinct, and limb muscle abnormalities in both mice and humans harboring Pax3 mutations support this distinc- tion. The mechanisms by which Pax3 affects limb muscle development are unknown.
机译:Pax3是一种转录因子,其表达已被用作侧so突肌中成肌前体细胞的标志物,注定要迁移到肢体肌肉并在其内生长。越来越多的证据表明,轴向和阑尾肌肉的胚胎起源是截然不同的,而带有Pax3突变的小鼠和人类的肢体肌肉异常都支持这种区别。 Pax3影响肢体肌肉发育的机制尚不清楚。

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