Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis

Craig M. Crews; William S. Lane; Stuart L. Schreiber

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Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis

机译：Didemnin与负责婴儿神经元类脑脂质脂褐变的蛋白棕榈酰硫酯酶结合

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The marine natural product didemnin B, currently in clinical trials as an antitumor agent, has several potent biological activities apparently mediated by distinct mechanisms. Our initial investigation of didemnin B resulted in the discovery of its GTP-dependent binding of the trans- lation elongation factor EF1α. This finding is consistent with the protein synthesis inhibitory activity of didemnin B ob- served at intermediate concentrations.

机译：目前在临床试验中作为抗肿瘤剂的海洋天然产物双氢睾丸素B具有明显的不同机制介导的几种有效的生物活性。我们对迪地美宁B的初步研究导致发现了其与GTP依赖的翻译延伸因子EF1α的结合。这一发现与在中等浓度下观察到的双氢蝶呤B的蛋白质合成抑制活性一致。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第9期|p.4316-4319|共4页
作者
Craig M. Crews; William S. Lane; Stuart L. Schreiber;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Lipid thioesters derived from acylated proteins accumulate in infantile neuronal ceroid lipofuscinosis: Correction of the defect in lymphoblasts by recombinant palmitoyl-protein thioesterase [J] . Jui-Yun Lu, Linda A. Verkruyse, Sandra L. Hofmann Proceedings of the National Academy of Sciences of the United States of America . 1996,第19期

机译：来源于酰化蛋白的脂族硫酯积累在婴儿神经元性类脂褐质病中：通过重组棕榈酰蛋白硫酯酶纠正淋巴母细胞的缺陷
2. Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis [J] . HuJ., LuJ.-Y., WongA.M.S., Molecular genetics and metabolism . 2012,第1a2期

机译：在婴儿神经元类脑脂质脂褐变的临床前小鼠模型中，重组棕榈酰蛋白硫酯酶的静脉内大剂量酶替代疗法减少了内脏溶酶体的储存并适度延长了生存期
3. Human recombinant palmitoyl-protein thioesterase-1 (PPT1) for preclinical evaluation of enzyme replacement therapy for infantile neuronal ceroid lipofuscinosis. [J] . Lu JY, Hu J, Hofmann SL Molecular genetics and metabolism . 2010,第4期

机译：人类重组棕榈酰蛋白硫酯酶-1（PPT1）用于婴幼儿神经元类固醇脂褐变病的酶替代治疗的临床前评估。
4. Patient Management Framework Based on Cloud Computing Storage Resources: A Case Study for Neuronal Ceroid Lipofuscinosis [C] . F. P. Schwartz, V. R. S. Rocha, C. Benac, Conference on Pan American Health Care Exchanges;Conference on Global Medical Engineering Physics Exchanges . 2019

机译：基于云计算存储资源的患者管理框架：神经元类脂脂增多症的案例研究
5. Gene therapy and enzyme replacement in a mouse model of late infantile neuronal ceroid lipofuscinosis. [D] . Chang, Michael Chia Hsiu. 2009

机译：晚期婴儿神经元类固醇脂褐藻病小鼠模型中的基因治疗和酶替代。
6. Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis. [O] . C M Crews, W S Lane, S L Schreiber 1996

机译：Didemnin与负责婴幼儿神经元类固醇脂褐变的蛋白棕榈酰硫酯酶结合。
7. Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis. [O] . Crews, C M, Lane, W S, Schreiber, S L 1996

机译：Didemnin与负责婴幼儿神经元类固醇脂褐变的蛋白棕榈酰硫酯酶结合。

Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis

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