A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimer

Siu-Kwong Chan; Richard S. Mann

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A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimer

机译：同源蛋白质-齿外-DNA复合体的结构模型解释了异二聚体中HOX蛋白的选择

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The genes of the homeotic complex (HOX) encode DNA binding homeodomain proteins that control developmental fates by differentially regulating the transcrip- tion of downstream target genes. Despite their unique in vivo functions, disparate HOX proteins often bind to very similar DNA sequences in vitro. Thus, a critical question is how HOX proteins select the correct sets of target genes in vivo. The homeodomain proteins encoded by the Drosophila extradenticle gene and its mammalian homologues, the pbx genes, contrib.- ute to HOX specificity by cooperatively binding to DNA with HOX proteins.

机译：同源复合物（HOX）的基因编码与DNA结合的同源域蛋白，该蛋白通过差异调节下游靶基因的转录来控制发育命运。尽管它们具有独特的体内功能，但它们在体外常常与非常相似的DNA序列结合。因此，一个关键的问题是HOX蛋白如何在体内选择正确的靶基因组。果蝇齿外基因编码的同源结构域蛋白及其哺乳动物同源物pbx基因通过与HOX蛋白协同结合到DNA而对HOX特异性有贡献。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第11期|p.5223-5228|共6页
作者
Siu-Kwong Chan; Richard S. Mann;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex. [J] . Q Lu, M P Kamps Molecular and Cellular Biology . 1996,第4期

机译：Pbx1内的结构决定簇，该结构决定簇与含五肽的Hox蛋白介导协同DNA结合：提议建立Pbx1-Hox-DNA复合物模型。
2. Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex. [J] . Q Lu, M P Kamps Molecular and Cellular Biology . 1996,第4期

机译：Pbx1内的结构决定簇，该结构决定簇与含五肽的Hox蛋白介导协同DNA结合：提议建立Pbx1-Hox-DNA复合物模型。
3. Homeotic Function of Drosophila Bithorax-Complex miRNAs Mediates Fertility by Restricting Multiple Hox Genes and TALE Cofactors in the CNS [J] . GarauletD.L., CastellanosM.C., BejaranoF., Developmental cell . 2014,第6期

机译：果蝇Bithorax复杂的miRNA的同源功能通过限制中枢神经系统中的多个Hox基因和TALE辅因子介导生育力。
4. ACCOUNTING FOR COMPACTION IN PERMEABILITY MODELLING: EXAMPLE OF TURBIDITIC DEPOSITS IN A COMPLEX STRUCTURAL ENVIRONMENT [C] . Christine DUVAL, Marie Pascale PERRUCHOT, Patrick TURPIN SPWLA Annual Logging Symposium . 2014

机译：渗透性建模中压实的核算：复杂结构环境中的浊度沉积物的示例
5. Structural Determinants of DNA-binding Specificity for Hox Proteins. [D] . Liu, Peng. 2012

机译：Hox蛋白的DNA结合特异性的结构决定因素。
6. A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimer. [O] . S K Chan, R S Mann 1996

机译：同源蛋白质-齿外-DNA复合体的结构模型解释了异二聚体中HOX蛋白的选择。
7. A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimer. [O] . Chan, S K, Mann, R S 1996

机译：同源蛋白质-齿外-DNA复合体的结构模型解释了异二聚体中HOX蛋白的选择。

A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimer

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