Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway

Falk Weih; Rolf-Peter Ryseck; Lihong Chen

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Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway

机译：Nur77 / N10转基因胸腺细胞凋亡涉及Fas / Fas配体途径

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The orphan nuclear receptor Nur77/N10 has recently been demonstrated to be involved in apoptosis of T cell hybridomas. We report here that chronic expression of Nur77/N10 in thymocytes of transgenic mice results in a dramatic reduction of CD4~+CD8~+ double-positive as well as CD4~+CD8- and CD4-CD8~+ single-positive cell populations due to an early onset of apoptosis. CD4-CD8- double-negative and CD25~+ precursor cells, however, are unaffected.

机译：最近已证明孤儿核受体Nur77 / N10参与T细胞杂交瘤的凋亡。我们在这里报告说，Nur77 / N10在转基因小鼠胸腺细胞中的慢性表达导致CD4〜+ CD8〜+双阳性以及CD4〜+ CD8-和CD4-CD8〜+单阳性细胞群的急剧减少到细胞凋亡的早期发作。然而，CD4-CD8-双阴性和CD25 +前体细胞不受影响。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第11期|p.5533-5538|共6页
作者
Falk Weih; Rolf-Peter Ryseck; Lihong Chen;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Fas Apoptosis Inhibitory Molecule Regulates T Cell Receptor-mediated Apoptosis of Thymocytes by Modulating Akt Activation and Nur77 Expression [J] . Jianxin Huo, Shengli Xu, Kong-Peng Lam The Journal of biological chemistry . 2010,第16期

机译：通过调节AKT激活和NUR77表达调节T细胞受体介导的T细胞受体介导的T细胞受体介导的胸腺细胞凋亡
2. Apoptosis of Antigen-Specific T Lymphocytes upon the Engagement of CD8 by Soluble HLA Class I Molecules Is Fas Ligand/Fas Mediated: Evidence for the Involvement of p56lck, Calcium Calmodulin Kinase II, and Calcium-Independent Protein Kinase C Signaling Pathways and for NF-κB and NF-AT Nuclear Translocation [J] . Paola Contini, Massimo Ghio, Andrea Merlo, The journal of immunology . 2005,第11期

机译：Fas配体/ Fas介导了可溶性HLA I类分子与CD8结合后抗原特异性T淋巴细胞的凋亡：p56lck，钙调蛋白激酶II和钙独立蛋白激酶C信号通路以及NF-涉及的证据κB和NF-AT核易位
3. Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells. [J] . Bras A, Albar JP, Leonardo E, Cell death and differentiation . 2000,第3期

机译：神经酰胺诱导的细胞死亡不依赖于Fas / Fas配体途径，并且可以通过Nur77在A20 B细胞中的过度表达来预防。
4. A Novel Ginseng Saponin Metabolite-Induced Apoptosis in MHCC97-H Cells Involves Mitochondria-Mediated Pathway And Fas/Fasl Pathway Cross-Talking [C] . Gholam Reza Bad jian, rnDahlan Ismail, rnMohd.Shahwahid H.O, Proceedin of 2008 International Conference on Ginseng . 2008

机译：MHCC97-H细胞中新型人参皂苷代谢物诱导的细胞凋亡涉及线粒体介导的途径和Fas / Fasl途径的交叉讨论。
5. IL-12 inhibits the metastatic potential of osteosarcoma cells and induces tumor regression via a mechanism involving Fas/Fas ligand pathway. [D] . Lafleur, Elizabeth Ann. 2003

机译：IL-12通过涉及Fas / Fas配体途径的机制抑制骨肉瘤细胞的转移潜能并诱导肿瘤消退。
6. Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway. [O] . F Weih, R P Ryseck, L Chen, 1996

机译：nur77 / N10转基因胸腺细胞的凋亡涉及Fas / Fas配体途径。
7. Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway. [O] . Weih, F, Ryseck, R P, Chen, L, 1996

机译：nur77 / N10转基因胸腺细胞的凋亡涉及Fas / Fas配体途径。

Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway

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