Structure and conformational changes of DNA topoisomerase II visualized by electron microscopy

Patrick Schultz; Stephane Olland; Pierre Oudet

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Structure and conformational changes of DNA topoisomerase II visualized by electron microscopy

机译：电子显微镜观察DNA拓扑异构酶II的结构和构象变化

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Type II DNA topoisomerases, which create a transient gate in duplex DNA and transfer a second duplex DNA through this gate, are essential for topological transfor- mations of DNA in prokaryotic and eukaryotic cells and are of interest not only from a mechanistic perspective but also because they are targets of agents for anticancer and antimi- crobial chemotherapy.

机译：II型DNA拓扑异构酶在双链体DNA中产生一个瞬时门，并通过该门转移第二个双链体DNA，对于原核和真核细胞中DNA的拓扑转化是必不可少的，并且不仅在机理上是有意义的，而且还因为它们是抗癌和抗微生物化疗药物的靶标。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第12期|p.5936-5940|共5页
作者
Patrick Schultz; Stephane Olland; Pierre Oudet;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Structure and conformational changes of DNA topoisomerase II visualized by electron microscopy. [O] . P Schultz, S Olland, P Oudet, 1996

机译：通过电子显微镜观察DNA拓扑异构酶II的结构和构象变化。
7. Structure and conformational changes of DNA topoisomerase II visualized by electron microscopy. [O] . Schultz, P, Olland, S, Oudet, P, 1996

机译：通过电子显微镜观察DNA拓扑异构酶II的结构和构象变化。

Structure and conformational changes of DNA topoisomerase II visualized by electron microscopy

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