Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: Implications for nitric oxide signaling

Guillermo Garcia-Cardena; Phil Oh; Jianwei Liu

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Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: Implications for nitric oxide signaling

机译：通过棕榈酰化将一氧化氮合酶靶向内皮细胞小窝：一氧化氮信号传导的含义

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The membrane association of endothelial nitric oxide synthase (eNOS) plays an important role in the biosynthesis of nitric oxide (NO) in vascular endothelium. Previously, we have shown that in cultured endothelial cells and in intact blood vessels, eNOS is found primarily in the perinuclear region of the cells and in discrete regions of the plasma membrane, suggesting trafficking of the protein from the Golgi to specialized plasma membrane structures.

机译：内皮型一氧化氮合酶（eNOS）的膜缔合在血管内皮中一氧化氮（NO）的生物合成中起重要作用。以前，我们已经表明，在培养的内皮细胞和完整的血管中，eNOS主要存在于细胞的核周区域和质膜的离散区域，这表明蛋白质从高尔基体运输到特定的质膜结构。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6448-6453|共6页
作者
Guillermo Garcia-Cardena; Phil Oh; Jianwei Liu;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. PALMITOYLATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE IS NECESSARY FOR OPTIMAL STIMULATED RELEASE OF NITRIC OXIDE - IMPLICATIONS FOR CAVEOLAE LOCALIZATION [J] . Liu JW, Garciacardena G, Sessa WC Biochemistry . 1996,第41期

机译：内皮一氧化氮合酶的棕榈酰化是最佳刺激一氧化氮释放的必要-对肺泡定位的意义。
2. Catalpol ameliorates advanced glycation end product‐induced dysfunction of glomerular endothelial cells via regulating nitric oxide synthesis by inducible nitric oxide synthase and endothelial nitric oxide synthase [J] . Sun Weixiang, Gao Yuyan, Ding Yushi, IUBMB life . 2019,第9期

机译：通过诱导型一氧化氮合酶和内皮一氧化氮合酶和内皮一氧化氮合酶来调节一氧化氮合成，可通过调节一氧化氮合成来改善高级糖化末期产物诱导的肾小球内皮细胞功能障碍
3. Hydrogen sulfide facilities production of nitric oxide via the Akt/endothelial nitric oxide synthases signaling pathway to protect human umbilical vein endothelial cells from injury by angiotensin II [J] . Cui Jiasen, Zhuang Shunjiu, Qi Shaohong, Molecular medicine reports . 2017,第5aPta1期

机译：通过AKT /内皮一氧化氮合成的硫化氢设施产生一氧化氮，信号通路以保护人脐静脉内皮细胞免受血管紧张素II的损伤
4. Kruppel-like Factor 4 Promotes Differentiation of Endothelial Progenitor Cells into Endothelial cells by Up-regulating Endothelial Nitric Oxide Synthase [C] . Hougmei Dong, Jiabei Li, Mingbao Song, World Congress on Heart Disease . 2011

机译：KRUPPEL样因子4通过UP调节内皮一氧化氮合酶促进内皮祖细胞的分化为内皮细胞
5. Characterization of the interaction between endothelial nitric oxide synthase and heat shock protein 90: Implications foreNOS activation and nitric oxide release. [D] . Fontana, Jason Thomas. 2002

机译：内皮型一氧化氮合酶和热休克蛋白90相互作用的特征：提示forNOS激活和一氧化氮释放。
6. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. [O] . G García-Cardeña, P Oh, J Liu, 1996

机译：通过棕榈酰化将一氧化氮合酶靶向内皮细胞小窝：一氧化氮信号传导的含义。
7. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. [O] . García-Cardeña, G, Oh, P, Liu, J, 1996

机译：通过棕榈酰化将一氧化氮合酶靶向内皮细胞小窝：一氧化氮信号传导的含义。

Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: Implications for nitric oxide signaling

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