Efficient and specific ribozyme-mediated reduction of bovine α -lactalbumin expression in double transgenic mice

Phil J. LHuillier; Solange Soulier; Marie-Georges Stinnakre

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Efficient and specific ribozyme-mediated reduction of bovine α -lactalbumin expression in double transgenic mice

机译：有效和特定的核酶介导的双转基因小鼠中牛α-乳清蛋白表达的减少

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In nonribozyme expressing trans- enic mice, the level of bovine -lac mRNA and protein was not affected. The specificity of this activity is demonstrated by the absence of a reduction in the levels of the endogenous murine α-lac mRNA or protein. These results demonstrate the feasi- bility of ribozyme-mediated down-regulation of highly- expressed transcripts in transgenic animals.

机译：在表达非核酶的跨性别小鼠中，牛-lac mRNA和蛋白质的水平不受影响。该活性的特异性通过内源性鼠α-lacmRNA或蛋白水平的降低而没有得到证明。这些结果证明了核酶介导的下调转基因动物中高表达转录本的可行性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6698-6703|共6页
作者
Phil J. LHuillier; Solange Soulier; Marie-Georges Stinnakre;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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专利

1. The bovine a‐lactalbumin promoter directs expression of ovine trophoblast interferon in the mammary gland of transgenic mice (1991) FEBS Letters 284, 19‐22 [J] . FEBS Letters . 1991,第1a2期

机译：牛α-乳白蛋白启动子指导绵羊滋养层干扰素在转基因小鼠的乳腺中的表达（1991）FEBS Letters 284，19-22
2. The bovine α‐lactalbumin promoter directs expression of ovine trophoblast interferon in the mammary gland of transgenic mice [J] . Charlier M., Gaye P., LHaridon R., FEBS Letters . 1991,第1期

机译：牛α-乳清蛋白启动子指导绵羊滋养细胞干扰素在转基因小鼠乳腺中的表达
3. A 5'-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice. [J] . Ramirez A, Vidal M, Bravo A, Proceedings of the National Academy of Sciences of the United States of America . 1995,第11期

机译：牛角蛋白6基因的5'上游区域在转基因小鼠中赋予组织特异性表达和过度增殖相关诱导。
4. Construction of SMYD3 liver-specific expression transgene for the eestablishment of transgenic mice [C] . Luo Xue-Gang, Ting-Ting Qin, Zhong-Shuai Xin, 2010 International Conference on Bioinformatics and Biomedical Technology (ICBBT 2010) . 2010

机译：用于建立转基因小鼠的SMYD3肝特异性表达转基因的构建
5. Growth Hormone (GH) and the Cardiovascular System: Studies in Bovine GH Transgenic and Inducible, Cardiac-Specific GH Receptor Gene Disrupted Mice. [D] . Jara, Adam. 2014

机译：生长激素（GH）和心血管系统：牛GH转基因和可诱导的，特定于心脏的GH受体基因破坏小鼠的研究。
6. Efficient and specific ribozyme-mediated reduction of bovine alpha-lactalbumin expression in double transgenic mice. [O] . P J LHuillier, S Soulier, M G Stinnakre, 1996

机译：有效和特定的核酶介导的双转基因小鼠中牛α-乳清蛋白表达的减少。
7. Efficient and specific ribozyme-mediated reduction of bovine alpha-lactalbumin expression in double transgenic mice. [O] . L'Huillier, P J, Soulier, S, Stinnakre, M G, 1996

机译：有效和特定的核酶介导的双转基因小鼠中牛α-乳清蛋白表达的减少。
8. Development and Characterization of Transgenic Mice with Mammary Gland Specific Expression of the Tumor Suppressor. [R] . Mao, M., Cuevas, B. D. 2002

机译：肿瘤抑制因子乳腺特异性表达转基因小鼠的研制与鉴定。

Efficient and specific ribozyme-mediated reduction of bovine α -lactalbumin expression in double transgenic mice

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