A melanoma-specific V_H antibody cloned from a fusion phage library of a vaccinated melanoma patient

Xiaohong Cai; Alan Garen

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A melanoma-specific V_H antibody cloned from a fusion phage library of a vaccinated melanoma patient

机译：从疫苗接种的黑色素瘤患者的融合噬菌体文库中克隆出黑色素瘤特异性V_H抗体

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摘要

The human antimelanoma antibody V86 was cloned from a single-chain Fv molecule (scFv) fusion phage library displaying the heavy chain variable domain (V_H) and light chain variable domain (V_L) repertoire of a melanoma patient immunized with genetically-modified autologous tu- mor cells. Previous ELISA tests for binding of the V86 fusion phage to a panel of human metastatic melanoma and carci- noma cell lines and primary cultures of normal melanocytes, endothelial, and fibroblast cells showed that measurable binding occurred only to the melanoma cells.

机译：从单链Fv分子（scFv）融合噬菌体库中克隆了人anlanlanoma抗体V86，该库显示了用基因修饰的自体tu-免疫的黑素瘤患者的重链可变域（V_H）和轻链可变域（V_L）组成mor细胞。以前的ELISA测试表明，V86融合噬菌体与一组人类转移性黑素瘤和癌细胞系以及正常黑素细胞，内皮细胞和成纤维细胞的原代培养物结合，表明可测量的结合仅发生于黑素瘤细胞。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6280-6285|共6页
作者
Xiaohong Cai; Alan Garen;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. Comparison of fusion phage libraries displaying V_H or single-chain Fv antibody fragments derived from the antibody repertoire of a vaccinated melanoma patient as a source of melanoma-specific targeting molecules [J] . Xiaohong Cai, Alan Garen Proceedings of the National Academy of Sciences of the United States of America . 1997,第17期

机译：融合噬菌体文库的比较，这些文库展示了来自已接种黑色素瘤患者抗体库中的V_H或单链Fv抗体片段，作为黑色素瘤特异性靶向分子的来源
2. Anti-melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor cells: selection of specific antibodies from single-chain Fv fusion phage libraries. [J] . Cai X, Garen A Proceedings of the National Academy of Sciences of the United States of America . 1995,第14期

机译：用基因修饰的自体肿瘤细胞免疫的黑色素瘤患者的抗黑色素瘤抗体：从单链Fv融合噬菌体文库中选择特异性抗体。
3. Magnetic Separation of Melanoma-Specific Cytotoxic T Lymphocytes from a Vaccinated Melanoma Patient's Blood Using MHC/Peptide Complex-Conjugated Bacterial Magnetic Particles [J] . Masayuki Takahashi, Yasuto Akiyama, Junpei Ikezumi Bioconjugate Chemistry . 2009,第2期

机译：使用MHC /肽复合物结合的细菌磁性颗粒从疫苗接种的黑色素瘤患者血液中磁性分离黑素瘤特异性细胞毒性T淋巴细胞
4. High Throughput Cytotoxicity Screening of Anti-HER2 Immunotoxins Conjugated with Antibody Fragments from Phage-Displayed Synthetic Antibody Libraries [C] . Hong-Sen Chen, Shin-Chen Hou, Hung-Wei Lin, PEGS . 2016

机译：与噬菌体展示合成抗体文库的抗体片段缀合的抗HER2免疫毒素的高通量细胞毒性筛选
5. Applications of phage-displayed antibody library for antibody discovery and engineering. [D] . Zhao, Qi. 2008

机译：噬菌体展示抗体库在抗体发现和工程设计中的应用。
6. A melanoma-specific VH antibody cloned from a fusion phage library of a vaccinated melanoma patient. [O] . X Cai, A Garen 1996

机译：从疫苗接种的黑色素瘤患者的融合噬菌体文库中克隆出黑色素瘤特异性VH抗体。
7. A melanoma-specific VH antibody cloned from a fusion phage library of a vaccinated melanoma patient. [O] . Cai, X, Garen, A 1996

机译：从疫苗接种的黑色素瘤患者的融合噬菌体文库中克隆出黑色素瘤特异性VH抗体。
8. Phage Display Breast Carcinoma cDNA Libraries: Isolation of Clones Which Specifically Bind to Membrane Glycoproteins, Mucins, and Endothelial Cell Surface [R] . Yamamoto, F. 2001

机译：噬菌体展示乳腺癌cDNa文库：分离与膜糖蛋白，粘蛋白和内皮细胞表面特异性结合的克隆

A melanoma-specific V_H antibody cloned from a fusion phage library of a vaccinated melanoma patient

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