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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Infectivity of chimeric human T-cell leukemia virus type I molecular clones assessed by naked DNA inoculation
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Infectivity of chimeric human T-cell leukemia virus type I molecular clones assessed by naked DNA inoculation

机译:通过裸DNA接种评估嵌合型人T细胞白血病病毒I型分子克隆的感染性

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摘要

Two human T-cell leukemia virus type I (HTLV-I) molecular clones, K30p and K34p were derived from HTLV-I-infected rabbit cell lines. K30p and K34p differ by 18 bp with changes in the long terminal repeats (LTRs) as well as in the gag, pol, and rex but not tax or env gene products. Cells transfected with clone K30p were infectious in vitro and injection of the K30p transfectants or naked K30p DNA into rabbits leads to chronic infection.
机译:两个人T细胞白血病病毒I型(HTLV-1)分子克隆K30p和K34p均来自感染HTLV-1的兔细胞系。 K30p和K34p相差18 bp,其长末端重复序列(LTR)以及gag,pol和rex的变化均不相同,但不包括tax或env基因产物。用克隆K30p转染的细胞在体外具有感染性,并且将K30p转染子或裸K30p DNA注射到兔子体内会导致慢性感染。

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