Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells

Veronique Le Cabec; Jack B. Cowland; Jero Calafat

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Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells

机译：将蛋白质靶向颗粒亚群是通过时间而不是通过排序来确定的：当在HL-60细胞中表达时，特定的颗粒蛋白质NGAL定位于嗜蓝粒颗粒

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The mechanism of protein targeting to indi- vidual granules in cells that contain different subsets of storage granules is poorly understood. The neutrophil con- tains two highly distinct major types of granules, the perox- idase positive (azurophil) granules and the peroxidase nega- tive (specific and gelatinase) granules. We hypothesized that targeting of proteins to individual granule subsets may be determined by the stage of maturation of the cell, at which the granule proteins are synthesized, rather than by individual sorting information present in the proteins.

机译：蛋白质靶向包含不同存储颗粒子集的细胞中单个颗粒的机制了解甚少。中性粒细胞包含两种高度不同的主要颗粒，即过氧化物酶阳性（嗜酸性）颗粒和过氧化物酶阴性（特异性和明胶酶）颗粒。我们假设将蛋白质靶向单个颗粒亚群可能是由细胞的成熟阶段决定的，在该阶段合成颗粒蛋白质，而不是通过蛋白质中存在的单独分类信息来确定。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6454-6457|共4页
作者
Veronique Le Cabec; Jack B. Cowland; Jero Calafat;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Specific and azurophilic granules from rabbit polymorphonuclear leukocytes. II. Cell surface localization of granule membrane and content proteins before and after degranulation [J] . WJ Brown, WA Shannon, WJ Snell Journal of cell biology . 1983,第4期

机译：来自兔多形核白细胞的特异和嗜酸性颗粒。二。脱粒前后颗粒表面的细胞表面定位和蛋白质含量
2. Sorting of neutrophil-specific granule protein human cathelicidin, hCAP-18, when constitutively expressed in myeloid cells. [J] . Bulow E, Bengtsson N, Calafat J, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2002,第1期

机译：当在髓样细胞中组成性表达时，对中性粒细胞特异性颗粒蛋白人类cathelicidin hCAP-18的分选。
3. A specific drug targeting system based on polyhydroxyalkanoate granule binding protein PhaP fused with targeted cell ligands. [J] . Yao YC, Zhan XY, Zhang J, Biomaterials . 2008,第36期

机译：基于与目标细胞配体融合的聚羟基链烷酸酯颗粒结合蛋白PhaP的特定药物靶向系统。
4. Starch granule formation and protein deposition in wheat (Triticum aestivum L.) starchy endosperm cells is altered by high temperature during grain fill [C] . William J. Hurkman, Delilah F. Wood Conference on scanning microscopy . 2010

机译：小麦籽粒填充过程中的高温改变了小麦（Triticum aestivum L.）淀粉质胚乳细胞中淀粉颗粒的形成和蛋白质沉积
5. BIOSYNTHESIS, POST-TRANSLATIONAL PROCESSING AND PACKAGING OF MYELOPEROXIDASE INTO AZUROPHIL GRANULES IN HL-60 CELLS (LYSOSOMES, LEUKEMIA). [D] . AKIN, DIANNE THOMAS. 1986

机译：在HL-60细胞（溶菌酶，白血病）中，髓氧合酶的生物合成，翻译后处理和包装成天竺葵颗粒。
6. Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells. [O] . V Le Cabec, J B Cowland, J Calafat, 1996

机译：将蛋白质靶向颗粒亚群是通过时间而不是通过排序来确定的：当在HL-60细胞中表达时特定的颗粒蛋白质NGAL定位于嗜蓝粒颗粒。
7. Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells. [O] . Le Cabec, V, Cowland, J B, Calafat, J, 1996

机译：将蛋白质靶向颗粒亚群是通过时间而不是通过排序来确定的：当在HL-60细胞中表达时，特定的颗粒蛋白质NGAL定位于嗜蓝粒颗粒。
8. Ca(2+)/Calmodulin-Dependent Protein Kinase Enriched in Cerebellar Granule Cells: Identification of a Novel Neuronal Calmodulin-Dependent Protein Kinase [R] . Ohmstede, C. A., Jensen, K. F., Sahyoun, N. E. 1989

机译：钙（2 +）/钙调蛋白依赖性蛋白激酶富含小脑颗粒细胞：鉴定新型神经元钙调蛋白依赖性蛋白激酶

Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells

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