Targeted mutation of Ncam to produce a secreted molecule results in a dominant embryonic lethality

Joseph E. Rabinowitz; Urs Rutishauser; Terry Magnuson

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Targeted mutation of Ncam to produce a secreted molecule results in a dominant embryonic lethality

机译：Ncam靶向突变产生分泌分子导致胚胎致死力

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The neural cell adhesion molecule (NCAM) is a membrane-associated member of the immunoglobulin superfamily capable of both homophilic and heterophilic binding. To investigate the significance of this binding, a gene targeting strategy in embryonic stem (ES) cells was used to replace the membrane-associated forms of NCAM with a soluble, secreted form of its extracellular domain. Although the heterozygous mutant ES cells were able to generate low coat color chimeric mice, only the wild-type allele was trans- mitted, suggesting the possibility of dominant lethality.

机译：神经细胞粘附分子（NCAM）是免疫球蛋白超家族的膜相关成员，能够同时进行亲和和异源结合。为了研究这种结合的重要性，在胚胎干（ES）细胞中的基因靶向策略被用来以其细胞外域的可溶，分泌形式代替NCAM的膜相关形式。尽管杂合的突变ES细胞能够产生低毛色的嵌合小鼠，但仅野生型等位基因得以传播，这提示了致命性致死的可能性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6421-6424|共4页
作者
Joseph E. Rabinowitz; Urs Rutishauser; Terry Magnuson;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Dominant maternal-effect mutations causing embryonic lethality in Caenorhabditis elegans. [J] . I A Sulston, P E Mains, W B Wood Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 1990,第2期

机译：导致秀丽隐杆线虫胚胎致死的主要母体效应突变。
2. DIFFERENCE IN THE RATIO OF DOMINANT-LETHAL MUTATIONS TO HERITABLE TRANSLOCATIONS PRODUCED IN MOUSE SPERMATIDS AND FULLY MATURE SPERM AFTER TREATMENT WITH TRIETHYLENEMELAMINE (TEM) [J] . C. S. Hellwig, C. V. Cornett, C. Y. Horton, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 1982,第4期

机译：三乙胺（TEM）处理后小鼠精子和完全成熟精子中可诱导的易位转位的显性-致死突变比有所不同
3. Small Molecule Targeting of a Myosin Partner Restores an Intact Keratin Cytoskeleton Despite Presence of a Dominant Keratin Mutation [J] . Bohnekamp Jens, Magin Thomas M. Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2015,第6期

机译：小分子靶向肌球蛋白伴侣恢复尽管完整的角蛋白突变存在完整的角蛋白细胞骨架。
4. Early Embryonic Lethality Caused by Targeted Disruption of the Mouse PHGPx Gene [C] . H. Imai, F. Hirao, T. Sakamoto, International Society for Free Radical Research . 2006

机译：通过针对小鼠PHGPX基因的靶向破坏引起的早期胚胎致死性
5. Targeted mutation of NCAM to produce a secreted molecule resulting in a dominant embryonic lethality. [D] . Rabinowitz, Joseph Elias. 1996

机译：NCAM的靶向突变，产生分泌的分子，导致占主导地位的胚胎致死率。
6. Targeted mutation of Ncam to produce a secreted molecule results in a dominant embryonic lethality. [O] . J E Rabinowitz, U Rutishauser, T Magnuson 1996

机译：Ncam靶向突变产生分泌分子会导致显着的胚胎致死性。
7. Targeted mutation of Ncam to produce a secreted molecule results in a dominant embryonic lethality. [O] . Rabinowitz, J E, Rutishauser, U, Magnuson, T 1996

机译：Ncam靶向突变产生分泌分子会导致显着的胚胎致死性。
8. DNA Target Sites Associated with Chemical Induction of Dominant-Lethal Mutations and Heritable Translocations in Mice [R] . Generoso, W. M., Cain, K. T., Cornett, C. C., 1983

机译：DNa靶位点与小鼠显性致死突变和可遗传易位的化学诱导相关

Targeted mutation of Ncam to produce a secreted molecule results in a dominant embryonic lethality

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