Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: Subregional mapping of chromosome 4 in cervical carcinoma

Garret M. Hampton; Amy A. Larson; Rebecca N. Baergen

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: Subregional mapping of chromosome 4 in cervical carcinoma

【24h】

Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: Subregional mapping of chromosome 4 in cervical carcinoma

机译：使用半自动基于荧光的检测同时评估多个微卫星基因座杂合性的丧失：子宫颈癌第4号染色体的分区图

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Detection of loss of heterozygosity (LOH) by comparison of normal and tumor genotypes using PCR-based microsatellite loci provides considerable advantages over tra- ditional Southern blotting-based approaches. However, cur- rent methodologies are limited by several factors, including the numbers of loci that can be evaluated for LOH in a single experiment, the discrimination of true alleles versus "stutter bands," and the use of radionucleotides in detecting PCR products.

机译：与基于传统Southern印迹的方法相比，使用基于PCR的微卫星基因座比较正常基因型和肿瘤基因型来检测杂合性缺失（LOH）具有明显优势。但是，当前的方法受到几个因素的限制，包括可以在单个实验中评估LOH的基因座数量，真实等位基因与“杂散谱带”的区分以及在检测PCR产物中使用放射性核苷酸。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6704-6709|共6页
作者
Garret M. Hampton; Amy A. Larson; Rebecca N. Baergen;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. X chromosomal and autosomal loss of heterozygosity and microsatellite instability in human cervical carcinoma. [J] . Edelmann J, Richter K, Hanel C, International journal of gynecological cancer: official journal of the International Gynecological Cancer Society . 2006,第3期

机译：人宫颈癌的X染色体和常染色体缺失杂合性和微卫星不稳定性。
2. Relationship between loss of heterozygosity at microsatellite loci and computerized nuclear morphometry in hepatocellular carcinoma. [J] . Suzuki K, Hirooka Y, Tsujitani S, Anticancer Research: International Journal of Cancer Research and Treatment . 2000,第2B期

机译：肝细胞癌中微卫星基因座杂合性丧失与计算机核形态测定之间的关系。
3. Detection of Loss of Heterozygosity (LOH) Using Circulating Cell-free DNA (cfDNA) by Fluorescence-based Multiplex PCR for Identification of Patients With Prostate Cancer [J] . S-Mary am Seyedolmohadessin, Mohammad T. Akbari, Zahra Nourmohammadi, Applied immunohistochemistry and molecular morphology: AIMM . 2018,第10期

机译：通过荧光的多重PCR检测使用循环无细胞DNA（CFDNA）的杂合性（LOH）的丧失，用于鉴定前列腺癌患者
4. An Ensemble Feature Ranking Framework for the Assessment of the Efficacy of Cervical Cancer Detection Tests and Human Papillomavirus Genotypes in the Detection of High-grade Cervical Intraepithelial Neoplasia and Cervical Carcinoma [C] . Panagiotis Bountris, Charalampos Tsirmpas, Maria Haritou, IEEE International Conference on Bioinformatics and Bioengineering . 2015

机译：合奏特征为评估宫颈癌检测试验和人乳头瘤病毒基因型在检测高级宫颈上皮内瘤和宫颈癌中的疗效进行评估框架
5. Integrated mapping and gene analysis in regions showing loss of heterozygosity in human breast cancer in the short arm of Chromosome 1. [D] . Baptista, Pedro M.R.V. 2000

机译：在染色体1的短臂中显示人类乳腺癌杂合性缺失的区域中的综合作图和基因分析。
6. Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: subregional mapping of chromosome 4 in cervical carcinoma. [O] . G M Hampton, A A Larson, R N Baergen, 1996

机译：使用半自动基于荧光的检测同时评估多个微卫星基因座杂合性的丧失：子宫颈癌第4号染色体的分区图。
7. Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: subregional mapping of chromosome 4 in cervical carcinoma. [O] . Hampton, G M, Larson, A A, Baergen, R N, 1996

机译：使用半自动基于荧光的检测，同时评估多个微卫星基因座杂合性的丧失：子宫颈癌第4号染色体的分区图。

Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: Subregional mapping of chromosome 4 in cervical carcinoma

摘要

著录项

相似文献

相关主题

期刊订阅