Microsatellite spreading in the human genome: Evolutionary mechanisms and structural implications

Eyal Nadir; Hanah Margalit; Tamar Gallily

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Microsatellite spreading in the human genome: Evolutionary mechanisms and structural implications

机译：微卫星在人类基因组中的传播：进化机制和结构意义。

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Microsatellites are tandem repeat sequences abundant in the genomes of higher eukaryotes and hitherto considered as "junk DNA." Analysis of a human genome representative data base (2.84 Mb) reveals a distinct juxta- position of A-rich microsatellites and retroposons and sug- gests their coevolution. The analysis implies that most mic- rosatellites were generated by a 3'-extension of retrotrans- cripts, similar to mRNA polyadenylylation, and that they serve in turn as "retroposition navigators," directing the retro- posons via homology-driven integration into defined sites.

机译：微卫星是在高级真核生物的基因组中丰富的串联重复序列，迄今被认为是“垃圾DNA”。对人类基因组代表数据库（2.84 Mb）的分析揭示了富含A的微卫星和反座子的并列位置，并建议它们共同进化。该分析表明，大多数微硅钙石是通过逆转录的3'延伸产生的，类似于mRNA多腺苷酸化作用，它们反过来又充当“重新定位的导航剂”，通过同源性驱动整合将逆转录因子引导到已定义的网站。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6470-6475|共6页
作者
Eyal Nadir; Hanah Margalit; Tamar Gallily;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Microsatellite spreading in the human genome: evolutionary mechanisms and structural implications. [O] . E Nadir, H Margalit, T Gallily, 1996

机译：微卫星在人类基因组中的传播：进化机制和结构意义。
7. Microsatellite spreading in the human genome: evolutionary mechanisms and structural implications. [O] . Nadir, E, Margalit, H, Gallily, T, 1996

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Microsatellite spreading in the human genome: Evolutionary mechanisms and structural implications

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