Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2

Simon A. Jones; Marlene Wolf; Shixin Qin

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2

【24h】

Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2

机译：人嗜中性白细胞白介素8受体（IL-8R）的不同功能：NADPH氧化酶和磷脂酶D通过IL-8R1激活，但不通过IL-8R2激活

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Two monoclonal antibodies, anti-IL8R1 and anti-IL8R2, raised against both interleukin 8 receptors (IL-8R) of human neutrophils, IL-8R1 and IL-8R2, were used to study individual receptor functions after stimulation with IL-8, GROα, or NAP-2. Efficacy and selectivity of the antibodies were tested in Jurkat cells transfected with cDNA coding for one or the other receptor. The binding of ~125I-labeled IL-8 and IL-8-induced changes of the cytosolic free Ca~2+ concentration were inhibited by anti-IL8R1 in cells expressing IL-8R1 and by anti-IL8R2 in cells expressing IL-8R2.

机译：针对人类中性粒细胞的白介素8受体（IL-8R）和IL-8R1和IL-8R2的两种抗IL8R1和IL8R2单克隆抗体，用于研究用IL-8，GROα刺激后的单个受体功能或NAP-2。在用编码一种或另一种受体的cDNA转染的Jurkat细胞中测试了抗体的功效和选择性。〜125I标记的IL-8的结合和IL-8诱导的胞浆游离Ca〜2 +浓度变化受到表达IL-8R1的细胞中抗IL8R1和表达IL-8R2的细胞中抗IL8R2的抑制。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第13期|p.6682-6686|共5页
作者
Simon A. Jones; Marlene Wolf; Shixin Qin;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Cytosolic phospholipase A(2) and its mode of activation in human neutrophils by opsonized zymosan - Correlation between 42/44 kDa mitogen-activated protein kinase, cytosolic phospholipase A(2) and NADPH oxidase [J] . Hazan I, Dana R, Granot Y, The Biochemical Journal . 1997,第Pta3期

机译：调理性酵母聚糖在人中性粒细胞中的胞质磷脂酶A（2）及其活化模式-42/44 kDa丝裂原活化蛋白激酶，胞质磷脂酶A（2）和NADPH氧化酶之间的相关性
2. Cytosolic phospholipase A2 and its mode of activation in human neutrophils by opsonized zymosan: Correlation between 42/44?kDa mitogen-activated protein kinase, cytosolic phospholipase A2 and NADPH oxidase [J] . Inbal HAZAN, Rachel LEVY, Raya DANA, The biochemical journal . 1997,第3期

机译：调理酵母聚糖在人中性粒细胞中的胞质磷脂酶A2及其活化方式：42 / 44kDa丝裂原活化蛋白激酶，胞质磷脂酶A2和NADPH氧化酶之间的相关性
3. Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but is essential for concomitant NADPH oxidase activation: studies with a staurosporine analogue with improved selectivity for protein kinase C [J] . A J Verhoeven, G C Kessels, K H Krause The biochemical journal . 1993,第3期

机译：蛋白激酶C的活性不参与N-甲酰基甲硫基-亮氨酰-苯丙氨酸在人嗜中性粒细胞中诱导的磷脂酶D的活化，但对于伴随的NADPH氧化酶活化是必不可少的：用星形孢菌素类似物进行研究，提高了蛋白激酶C的选择性
4. Activation of the neutrophil NADPH oxidase by Aspergillus fumigatus [C] . Keith B. Boyle, Len R. Stephens, Phillip T. Hawkins Advances Against Aspergillosis Conference . 2012

机译：Aspergillus Fumigatus的中性粒细胞NADPH氧化酶的激活
5. Regulatory mechanisms of neutrophil NADPH oxidase activation [D] . Chen, Jia 2010

机译：中性粒细胞NADPH氧化酶活化的调控机制
6. Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2. [O] . S A Jones, M Wolf, S Qin, 1996

机译：人类嗜中性白细胞白介素8受体（IL-8R）的功能不同：NADPH氧化酶和磷脂酶D是通过IL-8R1激活的而不是通过IL-8R2激活的。
7. Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2. [O] . Jones, S A, Wolf, M, Qin, S, 1996

机译：人类嗜中性白细胞白介素8受体（IL-8R）的功能不同：NADPH氧化酶和磷脂酶D是通过IL-8R1激活的，而不是通过IL-8R2激活的。
8. Costimulation of T Cell Receptor/CD3-Mediated Activation of Resting Human CD4+ TCells by Leukocyte Function-Associated Antigen-1 Ligand Intercellular Cell Adhesion Molecule-1 Involves Prolonged Inositol Phospholipid Hydrolysis and Sustained Increase of In [R] . Van Seventer, G. A., Bonvini, E., Yamada, H., 1992

机译：白细胞功能相关抗原-1配体细胞间粘附分子-1的T细胞受体/ CD3介导的静息人CD4 + TCell活化共刺激涉及延长的肌醇磷脂水解和持续增加的In

Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2

摘要

著录项

相似文献

相关主题

期刊订阅