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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >DP-2, a heterodimeric partner of E2F: Identification and characterization of DP-2 proteins expressed in vivo
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DP-2, a heterodimeric partner of E2F: Identification and characterization of DP-2 proteins expressed in vivo

机译:DP-2,E2F的异二聚体伴侣:体内表达的DP-2蛋白的鉴定和表征

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摘要

E2F is a heterodimeric transcription factor that regulates the expression of genes at the G1/S boundary and is composed of two related but distinct families of proteins, E2F and DP. E2F/DP heterodimers form complexes with the retinoblastoma (Rb) protein, the Rb-related proteins p107 and p130, and cyclins/cdks in a cell cycle-dependent fashion in vivo. E2F is encoded by at least five closely related genes, E2F-1 through -5. Here we report studies of DP-2, the second member of the DP family of genes.
机译:E2F是一种异二聚体转录因子,可调节G1 / S边界处的基因表达,并由两个相关但截然不同的蛋白质家族E2F和DP组成。 E2F / DP异二聚体在体内以细胞周期依赖的方式与视网膜母细胞瘤(Rb)蛋白,Rb相关蛋白p107和p130以及细胞周期蛋白/ cdks形成复合物。 E2F由至少五个紧密相关的基因E2F-1至-5编码。在这里,我们报告DP-2,DP基因家族的第二个成员的研究。

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