Sequence-specific recognition by cytosine C~5 and adenine N~6 DNA methyltransferases requires different deformations of DNA

Ricardo A. Garcia; Carlos J. Bustamante; Norbert O. Reich

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Sequence-specific recognition by cytosine C~5 and adenine N~6 DNA methyltransferases requires different deformations of DNA

机译：胞嘧啶C〜5和腺嘌呤N〜6 DNA甲基转移酶的序列特异性识别需要DNA的不同变形

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DNA methyltransferases modify specific cy- tosines and adenines within 2-6 bp recognition sequences. We used scanning force microscopy and gel shift analysis to show that M.HhaI, a cytosine C~5 DNA methyltransferase, causes only a 2 deg bend upon binding its recognition site. Our results are consistent with prior crystallographic analysis showing that the enzyme stabilizes an extrahelical base while leaving the DNA duplex otherwise unperturbed.

机译：DNA甲基转移酶可在2-6 bp的识别序列内修饰特定的胱氨酸和腺嘌呤。我们使用扫描力显微镜和凝胶位移分析显示，M.HhaI，胞嘧啶C〜5 DNA甲基转移酶，在结合其识别位点时仅引起2度弯曲。我们的结果与先前的晶体学分析一致，该分析表明该酶稳定了螺旋外碱基，同时使DNA双链体保持原状。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第15期|p.7618|共1页
作者
Ricardo A. Garcia; Carlos J. Bustamante; Norbert O. Reich;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases [J] . Albertas Timinskas, Arvydas Janulaitis, Danguolè Butkienè, Nucleic acids research . 1989,第23期

机译：DNA [胞嘧啶-N4]甲基转移酶的特征序列基序：与腺嘌呤和胞嘧啶-C5 DNA-甲基化酶的相似性
2. Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases [J] . Albertas Timinskas, Arvydas Janulaitis, Danguolè Butkienè, Nucleic acids research . 1989,第23期

机译：DNA [胞嘧啶-N4]甲基转移酶的特征序列基序：与腺嘌呤和胞嘧啶-C5 DNA-甲基化酶的相似性
3. M.?3TII: a new monospecific DNA (cytosine-C5) methyltransferase with pronounced amino acid sequence similarity to a family of adenine-N6-DNA-methyltransferases [J] . Jorn Walter, Mario Noyer Weidner, Peter-Andreas Terschuren, Nucleic acids research . 1994,第24期

机译：M.?3TII：一种新的单特异性DNA（胞嘧啶-C5）甲基转移酶，具有与腺嘌呤-N6-DNA-甲基转移酶家族明显的氨基酸序列相似性
4. Control of Mitochondrial DNA by Sequence-specific DNA-binding Molecules [C] . Takuya Hidaka, Ganesh Pandian Namasivayam 日本化学会春季年会講演予稿集 . 2018

机译：通过序列特异性DNA结合分子控制线粒体DNA
5. The structural basis of DNA recognition and base extrusion by a DNA cytosine-5 methyltransferase M.HaeIII. [D] . Didovyk, Andriy. 2010

机译：DNA胞嘧啶5甲基转移酶M.HaeIII的DNA识别和碱基挤出的结构基础。
6. Sequence-specific recognition of cytosine C5 and adenine N6 DNA methyltransferases requires different deformations of DNA. [O] . R A Garcia, C J Bustamante, N O Reich 1996

机译：胞嘧啶C5和腺嘌呤N6 DNA甲基转移酶的序列特异性识别需要DNA的不同变形。
7. Sequence-specific recognition of cytosine C5 and adenine N6 DNA methyltransferases requires different deformations of DNA. [O] . Garcia, R A, Bustamante, C J, Reich, N O 1996

机译：胞嘧啶C5和腺嘌呤N6 DNA甲基转移酶的序列特异性识别需要DNA的不同变形。

Sequence-specific recognition by cytosine C~5 and adenine N~6 DNA methyltransferases requires different deformations of DNA

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