Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: Identity with the receptor that binds to the globular 'heads' of C1q (gC1q-R)

Kusumam Joseph; Berhane Ghebrehiwet; Ellinor I. B. Peerschke

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Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: Identity with the receptor that binds to the globular 'heads' of C1q (gC1q-R)

机译：锌依赖性内皮细胞结合蛋白的高分子量激肽原和因子XII的鉴定：与结合到C1q的球状“头部”（gC1q-R）的受体相同

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High molecular weight kininogen (HK) and factor XII are known to bind to human umbilical vein endo- thelial cells (HUVEC) in a zinc-dependent and saturable manner indicating that HUVEC express specific binding site(s) for those proteins. However, identification and immu- nochemical characterization of the putative receptor site(s) has not been previously accomplished. In this report, we have identified a cell surface glycoprotein that is a likely candidate for the HK binding site on HUVECs.

机译：已知高分子量激肽原（HK）和XII因子以锌依赖性和饱和方式结合人脐静脉内皮细胞（HUVEC），表明HUVEC表达这些蛋白质的特异性结合位点。然而，先前尚未完成对假定受体位点的鉴定和免疫化学表征。在本报告中，我们鉴定了一种细胞表面糖蛋白，它可能是HUVEC上HK结合位点的候选基因。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第16期|p.8552-8557|共6页
作者
Kusumam Joseph; Berhane Ghebrehiwet; Ellinor I. B. Peerschke;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Soluble gC1q-R/p33, a cell protein that binds to the globular "heads" of C1q, effectively inhibits the growth of HIV-1 strains in cell cultures. [J] . Szabo J, Cervenak L, Toth FD, Clinical immunology: The official journal of the Clinical Immunology Society . 2001,第2期

机译：可溶性gC1q-R / p33是一种与C1q的球形“头部”结合的细胞蛋白，可有效抑制HIV-1菌株在细胞培养物中的生长。
2. High molecular weight kininogen and factor XII binding to endothelial cells and astrocytes. [J] . Fernando LP, Natesan S, Joseph K, Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 2003,第5期

机译：高分子量激肽原和因子XII与内皮细胞和星形胶质细胞结合。
3. The receptor for the globular "heads" of C1q, gC1q-R, binds to fibrinogen/fibrin and impairs its polymerization. [J] . Lu PD, Galanakis DK, Ghebrehiwet B, Clinical immunology: The official journal of the Clinical Immunology Society . 1999,第3期

机译：C1q的球状“头部”受体gC1q-R与血纤蛋白原/血纤蛋白结合并损害其聚合。
4. Vascular endothelial growth factor receptor 2 binding peptide:Targeting vascular endothelial cells [C] . Laimute Taraseviciene-stewart, John M.Stewart, Lajos Gera, European Peptide Symposium . 2002

机译：血管内皮生长因子受体2结合肽：靶向血管内皮细胞
5. A novel approach to control and regulate the classical complement pathway: Highly specific inhibition of C1q globular head binding to human IgG using an engineered single chain antibody variable fragment; recruiting C1q to HER2 /neu positive cells using truncated bispecific antibodies [D] . Hwang, Hee Young 2007

机译：一种控制和调节经典补体途径的新方法：使用工程化的单链抗体可变片段高度特异性地抑制C1q球头与人IgG的结合；使用截短的双特异性抗体将C1q募集到HER2 / neu阳性细胞
6. Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular heads of C1q (gC1q-R). [O] . K Joseph, B Ghebrehiwet, E I Peerschke, 1996

机译：高分子量激肽原和因子XII的锌依赖性内皮细胞结合蛋白的鉴定：与与C1q的球状头部结合的受体（gC1q-R）相同。
7. Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular "heads" of C1q (gC1q-R). [O] . Joseph, K, Ghebrehiwet, B, Peerschke, E I, 1996

机译：高分子量激肽原和因子XII的锌依赖性内皮细胞结合蛋白的鉴定：与与C1q的球状“头部”结合的受体（gC1q-R）相同。

Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: Identity with the receptor that binds to the globular 'heads' of C1q (gC1q-R)

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