Mammalian cells resistant to tumor suppressor genes

Jennifer A. Pietenpol; Christoph Lengauer; Jan Jordan

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Mammalian cells resistant to tumor suppressor genes

机译：抵抗肿瘤抑制基因的哺乳动物细胞

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Expression of p53 causes growth arrest or apoptosis in many normal and neoplastic cell types, but the relationship between these two effects has remained obscure. To begin to dissect the underlying mechanisms at a genetic level, we have generated mutant cells resistant to the action of wild-type p53. Rat embryo fibroblasts transformed with ras and a temperature-sensitive p53 (tsp53~135val) gene were chem.- ically mutagenized and selected for growth at a temperature at which p53 adopts a wild-type conformation (31.5 deg C).

机译：p53的表达在许多正常和赘生性细胞类型中导致生长停滞或凋亡，但是这两种作用之间的关系仍然不清楚。为了在基因水平上开始剖析潜在机制，我们已经产生了对野生型p53的作用有抗性的突变细胞。化学诱变并用ras和温度敏感的p53（tsp53〜135val）基因转化的大鼠胚胎成纤维细胞在p53呈野生型构象（31.5℃）的温度下生长。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第16期|p.8390-8394|共5页
作者
Jennifer A. Pietenpol; Christoph Lengauer; Jan Jordan;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model. [J] . Carnero A, Hudson JD, Hannon GJ, Nucleic Acids Research . 2000,第11期

机译：哺乳动物细胞功能丧失的遗传学：p53抑癌模型。
2. Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model [J] . Amancio Carnero, David H. Beach, Gregory J. Hannon, Nucleic acids research . 2000,第11期

机译：哺乳动物细胞功能丧失的遗传学：p53抑癌模型
3. Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. [J] . Huang J, Wu S, Wu CL Cancer research: The official organ of the American Association for Cancer Research, Inc . 2009,第15期

机译：雷帕霉素复合物2的哺乳动物靶标下游的信号传递事件在结节性硬化复合物肿瘤抑制因子缺乏的细胞和肿瘤中减弱。
4. Oncogenes and tumor suppressor genes in murine tumors induced by neutron- or gamma-irradiation in utero [C] . Sara Antal, K. Lumniczky, J. Palfalvi, International Symposium of Radiation and Homeostasis . 2002

机译：子宫中子或γ-辐照诱导的鼠肿瘤中的癌肠和肿瘤抑制基因
5. Transactivational activity of the tumor suppressor proteinp53 is dependent on thioredoxin reductase activity in mammalian cells. [D] . Merwin, Jason R. 2004

机译：肿瘤抑制蛋白p53的反式激活活性取决于哺乳动物细胞中硫氧还蛋白还原酶的活性。
6. Mammalian cells resistant to tumor suppressor genes. [O] . J A Pietenpol, C Lengauer, J Jordan, 1996

机译：对肿瘤抑制基因有抗性的哺乳动物细胞。
7. Mammalian cells resistant to tumor suppressor genes. [O] . Pietenpol, J A, Lengauer, C, Jordan, J, 1996

机译：对肿瘤抑制基因有抗性的哺乳动物细胞。
8. In-Vivo Characterization of Mammalian Polarity Genes as Novel Tumor Suppressors Involved in Breast Cancer Development and Progression in a Mouse Model [R] . Rosenberg, A. Z. 2006

机译：哺乳动物极性基因的体内表征作为新型肿瘤抑制因子参与乳腺癌的发展和小鼠模型的进展

Mammalian cells resistant to tumor suppressor genes

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