Mapping rat megalin: The second cluster of ligand binding repeats contains a 46-amino acid pathogenic epitope involved in the formation of immune deposits in Heymann nephritis

Akihiko Saito; Hajime Yamazaki; Katherine Rader

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Mapping rat megalin: The second cluster of ligand binding repeats contains a 46-amino acid pathogenic epitope involved in the formation of immune deposits in Heymann nephritis

机译：绘制大鼠巨蛋白图谱：配体结合重复序列的第二个簇包含一个46个氨基酸的病原性表位，参与Heymann肾炎中免疫沉积物的形成

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Megalin (gp330), an epithelial endocytic re- ceptor, is a major target antigen of Heymann nephritis (HN), an autoimmune disease in rats. To elucidate the mechanisms of HN, we have mapped a pathogenic epitope in megalin that binds anti-megalin antibodies. We focused our attention on four clusters of cysteine-rich, low density lipoprotein receptor (LDLR) ligand binding repeats in the extracellular domain of megalin because they represent putative ligand binding re- gions and therefore would be expected to be exposed in vivo and to be able to bind circulating antibodies.

机译：Megalin（gp330）是一种上皮内吞性受体，是大鼠自身免疫性疾病Heymann肾炎（HN）的主要靶抗原。为了阐明HN的机制，我们在巨蛋白中绘制了与抗巨蛋白抗体结合的致病抗原决定簇。我们将注意力集中在megalin胞外域中的四个富半胱氨酸，低密度脂蛋白受体（LDLR）配体结合重复簇上，因为它们代表推定的配体结合区域，因此有望在体内暴露并被暴露出来。能够结合循环抗体。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第16期|p.8601-8605|共5页
作者
Akihiko Saito; Hajime Yamazaki; Katherine Rader;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Initial events in the formation of immune deposits in passive Heymann nephritis. gp330-anti-gp330 immune complexes form in epithelial coated pits and rapidly become attached to the glomerular basement membrane. [J] . D Kerjaschki, A Miettinen, M G Farquhar The Journal of Experomental Medicine . 1987,第1期

机译：被动性Heymann肾炎中免疫沉积物形成的初始事件。 gp330-anti-gp330免疫复合物在上皮包被的小孔中形成，并迅速附着在肾小球基底膜上。
2. Comparative study of in situ immune deposit formation in active and passive Heymann nephritis [J] . Michael P Madaio, David J Salant, Andrew J Cohen, Kidney international. . 1983,第3期

机译：主动和被动Heymann肾炎原位免疫沉积物形成的比较研究
3. IDENTIFICATION OF THE SECOND CLUSTER OF LIGAND-BINDING REPEATS IN MEGALIN AS A SITE FOR RECEPTOR-LIGAND INTERACTIONS [J] . Orlando RA., Czekay RP., Yamazaki H., Proceedings of the National Academy of Sciences of the United States of America . 1997,第6期

机译：麦加林中配体重复序列的第二簇作为受体-配体相互作用的位点的鉴定
4. Mapping rat megalin: the second cluster of ligand binding repeats contains a 46-amino acid pathogenic epitope involved in the formation of immune deposits in Heymann nephritis. [O] . A Saito, H Yamazaki, K Rader, 1996

机译：绘制大鼠巨蛋白图谱：配体结合重复序列的第二个簇包含一个46个氨基酸的病原性表位参与Heymann肾炎中免疫沉积物的形成。
5. Mapping rat megalin: the second cluster of ligand binding repeats contains a 46-amino acid pathogenic epitope involved in the formation of immune deposits in Heymann nephritis. [O] . Saito, A, Yamazaki, H, Rader, K, 1996

机译：绘制大鼠巨蛋白图谱：配体结合重复序列的第二个簇包含一个46个氨基酸的病原性表位，与Heymann肾炎中的免疫沉积物形成有关。

Mapping rat megalin: The second cluster of ligand binding repeats contains a 46-amino acid pathogenic epitope involved in the formation of immune deposits in Heymann nephritis

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