Thymus transplantation, a critical factor for correction of autoimmune disease in aging MRL/+ mice

Naoki Hosaka; Masato Nose; Masahisa Kyogoku

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Thymus transplantation, a critical factor for correction of autoimmune disease in aging MRL/+ mice

机译：胸腺移植是纠正MRL / +衰老小鼠自身免疫性疾病的关键因素

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MRL/MP+/+ (MRL/+) mice develop pancreatitis and sialoadenitis after they reach 7 months of age. Conventional bone marrow transplantation has been found to be ineffective in the treatment of these forms of apparent autoimmune disease. Old MRL/+ mice show a dramatic thymic involution with age. Hematolymphoid recon- stitution is incomplete when fetal liver cells (as a source of hemopoietic stem cells) plus fetal bone (FB; which is used to recruit stromal cells) are transplanted from immunologically normal C57BL/6 donor mice to MRL/+ female recipients.

机译：MRL / MP + / +（MRL / +）小鼠在7个月大时会发展成胰腺炎和唾液腺炎。已发现常规的骨髓移植在治疗这些形式的表观自身免疫性疾病方面无效。年龄最大的MRL / +小鼠随着年龄增长显示出剧烈的胸腺退化。从免疫正常的C57BL / 6供体小鼠向MRL / +雌性受体移植胎儿肝细胞（作为造血干细胞的来源）和胎儿骨（FB；用于募集基质细胞）时，血淋巴重构不完全。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第16期|p.8558-8562|共5页
作者
Naoki Hosaka; Masato Nose; Masahisa Kyogoku;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. Treatment of autoimmune diseases in MRL/lpr mice by allogenic bone marrow transplantation plus adult thymus transplantation. [J] . Hosaka N, Ryu T, Miyake T, Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology . 2007,第3期

机译：同种异体骨髓移植加成年胸腺移植治疗MRL / lpr小鼠自身免疫性疾病。
2. Prevention of lpr-graft-versus-host disease and transfer of autoimmune diseases in normal C57BL/6 mice by transplantation of bone marrow cells plus bones (stromal cells) from MRL/lpr mice. [J] . Miyashima S, Nagata N, Nakagawa T, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1996,第1期

机译：通过从MRL / lpr小鼠移植骨髓细胞和骨骼（基质细胞）来预防正常C57BL / 6小鼠中的lpr移植物抗宿主病和自身免疫疾病的转移。
3. Prevention of lpr-graft-versus-host disease and transfer of autoimmune diseases in normal C57BL/6 mice by transplantation of bone marrow cells plus bones (stromal cells) from MRL/lpr mice. [J] . S Miyashima, N Nagata, T Nakagawa, The journal of immunology . 1996,第1期

机译：通过从MRL / lpr小鼠移植骨髓细胞和骨骼（基质细胞）来预防正常C57BL / 6小鼠中的lpr移植物抗宿主病和自身免疫疾病的转移。
4. Transplantation for autoimmune liver diseases [C] . J. NEUBERGE Falk Symposium . 2005

机译：移植自身免疫性肝病
5. Placental proteins, interleukin-12 and interleukin-15 influence the pathogenesis of autoimmune diseases in mice. [D] . Landek-Salgado, Melissa Anne. 2010

机译：胎盘蛋白，白介素12和白介素15影响小鼠自身免疫性疾病的发病机理。
6. Thymus transplantation a critical factor for correction of autoimmune disease in aging MRL/+mice. [O] . N Hosaka, M Nose, M Kyogoku, 1996

机译：胸腺移植是纠正MLR / +小鼠衰老中自身免疫疾病的关键因素。
7. Thymus transplantation, a critical factor for correction of autoimmune disease in aging MRL/+mice. [O] . Hosaka, N, Nose, M, Kyogoku, M, 1996

机译：胸腺移植是纠正MLR / +小鼠衰老中自身免疫疾病的关键因素。

Thymus transplantation, a critical factor for correction of autoimmune disease in aging MRL/+ mice

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