Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways

Yan-You Huang; Mary Elizabeth Bach; Hans-Peter Lipp

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Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways

机译：缺少编码组织型纤溶酶原激活物的基因的小鼠在Schaffer侧支和苔藓纤维途径中均表现出对后期长期增强的选择性干扰

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The gene encoding tissue-type plasminogen activator (t-PA) is an immediate response gene, downstream from CREB-1 and other constitutively expressed transcrip- ion factors, which is induced in the hippocampus during the late phase of long-term potentiation (L-LTP). Mice in which the t-PA gene has been ablated (t-PA) showed no gross anatomical, electrophysiological, sensory, or motor abnor- alities but manifest a selective reduction in L-LTP in hip- ocampal slices in both the Schaffer collateral-CA1 and mossy fiber-CA3 pathways.

机译：编码组织型纤溶酶原激活物（t-PA）的基因是一种即时反应基因，位于CREB-1和其他组成型表达转录因子的下游，在长时程增强的晚期阶段在海马中被诱导（L -LTP）。消融了t-PA基因的小鼠（t-PA）并未表现出明显的解剖，电生理，感觉或运动异常，但在Schaffer侧支中均显示出海马切片中L-LTP的选择性降低。 CA1和苔藓纤维-CA3途径。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第16期|p.8699-8704|共6页
作者
Yan-You Huang; Mary Elizabeth Bach; Hans-Peter Lipp;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Disabling G beta gamma-SNAP-25 interaction in gene-targeted mice results in enhancement of long-term potentiation at Schaffer collateral-CA1 synapses in the hippocampus [J] . Irfan Muhammad, Zurawski Zack, Hamm Heidi, Neuroreport . 2019,第10期

机译：禁用GβGamma-Snap-25在基因靶向小鼠中的相互作用导致Schaffer难民-CA1突触在海马中的长期增强
2. Identification of upregulated SCG10 mRNA expression associated with late-phase long-term potentiation in the rat hippocampal Schaffer-CA1 pathway in vivo. [J] . Peng H, Derrick BE, Martinez-JL Jr The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2003,第16期

机译：鉴定与大鼠海马Schaffer-CA1途径体内后期长期增强相关的SCG10 mRNA表达上调。
3. Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways [J] . Kyle R. Christensen, Thomas G. Beach, Geidy E. Serrano, Acta Neuropathologica Communications . 2019,第1期

机译：致病性tau修饰发生在长满苔藓的纤维和Schaffer侧支途径的树突状区室之前的轴突中
4. Identification of genes associated with late-phase long-term potentiation in the hippocampal Schaffer-CA1 pathway. [D] . Peng, Haixiang. 2003

机译：鉴定与海马Schaffer-CA1途径的晚期长期增强相关的基因。
5. Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways. [O] . Y Y Huang, M E Bach, H P Lipp, 1996

机译：缺乏编码组织型纤溶酶原激活物的基因的小鼠在Schaffer侧支和苔藓纤维途径中均表现出对后期长期增强的选择性干扰。
6. Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways [O] . Huang, Y Y, Bach, M E, Lipp, H P, 1996

机译：缺少编码组织型纤溶酶原激活物的基因的小鼠在Schaffer侧支和苔藓纤维途径中均表现出对后期长期增强的选择性干扰
7. Tissue-Plasminogen Activator Is Induced as an Immediate-Early Gene DuringSeizure, Kindling and Long-Term Potentiation [R] . Qian, Z., Gilbert, M. E., Colicos, M. A., 1993

机译：组织 - 纤溶酶原激活剂在癫痫发作，点燃和长期增强期间被诱导为即刻早期基因

Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways

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