Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor

Rong Wang; Ryuji Kobayashi; J. Michael Bishop

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Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor

机译：细胞粘附引起Met细胞表面受体的配体独立激活

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Cell adhesion has a fundamental role in the proliferation and motility of normal cells and the metastasis of tumor cells. To identify signaling pathways activated by the adherence of tumor cells, we analyzed the tyrosine phosphor- ylation of proteins in mouse melanoma cells before and after attachment to substrata. We discovered that cellular adher- ence activated the protein-tyrosine kinase of the cell surface receptor Met, whose ligand is hepatocyte growth factor and scatter factor.

机译：细胞粘附在正常细胞的增殖和运动以及肿瘤细胞的转移中具有基本作用。为了确定由肿瘤细胞粘附激活的信号通路，我们分析了小鼠黑素瘤细胞附着于基质之前和之后酪氨酸的磷酸化。我们发现细胞粘附激活了细胞表面受体Met的蛋白酪氨酸激酶，其配体为肝细胞生长因子和散射因子。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第16期|p.8425-8430|共6页
作者
Rong Wang; Ryuji Kobayashi; J. Michael Bishop;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor. [O] . R Wang, R Kobayashi, J M Bishop 1996

机译：细胞粘附引起Met细胞表面受体的配体独立激活。
7. Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor. [O] . Wang, R, Kobayashi, R, Bishop, J M 1996

机译：细胞粘附引起Met细胞表面受体的配体独立激活。

Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor

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