Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects

Mario Gimona; Jeffrey A. Kazzaz; David M. Helfman

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Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects

机译：原肌球蛋白2或3在v-Ki-ras转化的成纤维细胞中的强迫表达导致明显的表型效应

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Transformation of cells in tissue culture results in a variety of cellular changes including alterations in cell growth, adhesiveness, motility, morphology, and organi- ation of the cytoskeleton. Morphological and cytoskeletal changes are perhaps the most readily apparent features of transformed cells. Although a number of studies have docu- ented a decrease in the expression of specific tropomyosin (TM) isoforms in transformed cells, it remains to be deter- ined if the suppression of TM synthesis is essential in the establishment and maintenance of the transformed phenotype.

机译：组织培养中细胞的转化导致多种细胞变化，包括细胞生长，粘附性，运动性，形态和细胞骨架组织的改变。形态和细胞骨架变化也许是转化细胞最容易表现出来的特征。尽管许多研究表明转化细胞中特定原肌球蛋白（TM）同工型的表达降低，但是是否需要抑制TM合成对建立和维持转化表型至关重要。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9618-9623|共6页
作者
Mario Gimona; Jeffrey A. Kazzaz; David M. Helfman;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Forced expression of chimeric human fibroblast tropomyosin mutants affects cytokinesis. [J] . K S Warren, J L Lin, J P McDermott, Journal of cell biology . 1995,第3期

机译：嵌合人类成纤维细胞原肌球蛋白突变体的强迫表达影响胞质分裂。
2. Phenotypic effects of the forced expression of HNF4 and HNF1 alpha are conditioned by properties of the recipient cell [J] . Bailly A., Bender V., Weiss MC., Journal of Cell Science . 1998,第Pta16期

机译：HNF4和HNF1 alpha强制表达的表型效应受受体细胞特性的制约
3. Phenotypic effects of the forced expression of HNF4 and HNF1alpha are conditioned by properties of the recipient cell. [J] . Bailly A, Spath G, Bender V, Journal of Cell Science . 1998,第Pta16期

机译：HNF4和HNF1alpha的强制表达的表型效应受受体细胞的性质的制约。
4. The effects of mechanical distention on pulmonary alveolar epithelial phenotypic expression [C] . Jorge A.Gutierrez, Leland Dobbs Bioengineering conference . 1999

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5. Identifying biological pathways implicated in defined subgroups of phenotypic expression for autism spectrum disorders & evaluating small molecule effects on expression of ASMT [D] . Veatch, Olivia Jean 2013

机译：鉴定与自闭症谱系障碍表型表达亚组有关的生物学途径，并评估小分子对ASMT表达的影响
6. Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects. [O] . M Gimona, J A Kazzaz, D M Helfman 1996

机译：原肌球蛋白2或3在v-Ki-ras转化的成纤维细胞中的强迫表达导致明显的表型效应。
7. Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects. [O] . Gimona, M, Kazzaz, J A, Helfman, D M 1996

机译：原肌球蛋白2或3在v-Ki-ras转化的成纤维细胞中的强迫表达导致明显的表型效应。

Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects

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