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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract
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Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract

机译:1型纤维蛋白表达增强了尿道的大肠杆菌毒性

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摘要

Type 1 fimbriae are adhesion organelles ex- pressed by many Gram-negative bacteria. They facilitate adherence to mucosal surfaces and inflammatory cells in vitro, but their contribution to virulence has not been defined. This study presents evidence that type 1 fimbriae increase the virulence of Escherichia coli for the urinary tract by promoting bacterial persistence and enhancing the inflammatory re- sponse to infection.
机译:1型菌毛是许多革兰氏阴性细菌表达的粘附细胞器。它们在体外促进对粘膜表面和炎性细胞的粘附,但是它们对毒力的贡献尚未确定。这项研究提供了证据,即1型菌毛通过促进细菌的持久性和增强对感染的炎症反应而增加了尿道大肠杆菌的毒性。

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