The structure of bovine F_1-ATPase complexed with the peptide antibiotic efrapeptin

Jan Pieter Abrahams; Susan K. Buchanan; Mark J. van Raaij

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The structure of bovine F_1-ATPase complexed with the peptide antibiotic efrapeptin

机译：牛F_1-ATPase与肽抗菌素efrapeptin复合的结构

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In the previously determined structure of mitochondrial F_1-ATPase determined with crystals grown in the presence of adenylyl-imidodiphosphate (AMP-PNP) and ADP, the three catalytic β-subunits have different conforma- tions and nucleotide occupancies. AMP-PNP and ADP are bound to subunits β_TP and β_DP, respectively, and the third β-subunit (β_E) has no bound nucleotide. The efrapeptins are a closely related family of modified linear peptides containing 15 amino acids that inhibit both ATP synthesis and hydrolysis by binding to the F_1 catalytic domain of F_1F_o-ATP synthase.

机译：在先前确定的线粒体F_1-ATPase结构中，该结构是通过在腺苷酸-亚氨基二磷酸（AMP-PNP）和ADP存在下生长的晶体确定的，三个催化性β-亚基具有不同的构型和核苷酸占有率。 AMP-PNP和ADP分别与亚基β_TP和β_DP结合，并且第三个β亚基（β_E）没有结合核苷酸。 rapepteptins是一个密切相关的修饰线性肽家族，包含15个氨基酸，这些氨基酸通过与F_1F_o-ATP合酶的F_1催化域结合而抑制ATP合成和水解。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9420-9424|共5页
作者
Jan Pieter Abrahams; Susan K. Buchanan; Mark J. van Raaij;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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2. Bovine Neutrophil Antibiotic Peptides and Their Precursors: Structure and Role in Innate Immunity [J] . Domenico Romeo, Renato Gennaro, Margherita Zanetti, Croatica Chemica Acta . 1995,第3期

机译：牛中性粒细胞抗生素肽及其前体：结构和在先天免疫中的作用。
3. Bovine Neutrophil Antibiotic Peptides and Their Precursors: Structure and Role in Innate Immunity [J] . Gennaro Renato, Litteri Laura, Romeo Domenico, Croatica chemica acta . 1995,第3期

机译：牛中性粒细胞抗生素肽及其前体：结构和在先天免疫中的作用。
4. Nuclear magnetic resonance approach to search a target moleculefor new antibiotics,by the analysis of structure-activityrelationships of antimicrobial peptides [C] . (missing) International Beijing conference and exhibition on instrumental analysis . 2003

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5. Production, characterization, and elucidation of structure-function relationship of lactoferricin and other peptides derived from food-grade bovine lactoferrin. [D] . Chan, Judy Chuk Kwan. 2006

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6. The structure of bovine F1-ATPase complexed with the peptide antibiotic efrapeptin. [O] . J P Abrahams, S K Buchanan, M J Van Raaij, 1996

机译：牛F1-ATPase的结构与肽抗生素efrapeptin复合。
7. The structure of bovine F1-ATPase complexed with the peptide antibiotic efrapeptin. [O] . Abrahams, J P, Buchanan, S K, Van Raaij, M J, 1996

机译：牛F1-ATPase的结构与肽抗生素efrapeptin复合。
8. Annual Progress Report Structure and Antibiotic Activity of Peptides [R] . 1957

机译：年度进展报告结构和肽的抗生素活性

The structure of bovine F_1-ATPase complexed with the peptide antibiotic efrapeptin

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