The mode of action and the structure of a herbicide in complex with its target: Binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase

R. Fonne-Pfister; P. Chemla; E. Ward M. Girardet

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The mode of action and the structure of a herbicide in complex with its target: Binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase

机译：除草剂与其目标配合物的作用方式和结构：活化的hydantocidin与腺苷琥珀酸合成酶的反馈调节位点的结合

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摘要

(+)-Hydantocidin, a recently discovered nat- ural spironucleoside with potent herbicidal activity, is shown to be a proherbicide that, after phosphorylation at the 5' position, inhibits adenylosuccinate synthetase, an enzyme involved in de novo purine synthesis. The mode of binding of hydantocidin 5'-monophosphate to the target enzyme was analyzed by determining the crystal structure of the enzyme- inhibitor complex at 2.6-A deg resolution.

机译：（+）-Hydantocidin，一种新发现的具有有效除草活性的天然螺核苷，被证明是一种除草剂，在5'位磷酸化后抑制腺嘌呤琥珀酸酯合成酶，一种涉及从头嘌呤合成的酶。通过确定酶-抑制剂复合物在2.6-A deg分辨率下的晶体结构，分析了羟基龙胆素5'-单磷酸酯与目标酶的结合方式。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9431-9436|共6页
作者
R. Fonne-Pfister; P. Chemla; E. Ward M. Girardet;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Refined Crystal Structure of Adenylosuccinate Synthetase from Escherichia coli Complexed with Hydantocidin 5'-Phosphate, GDP, HPO_4~(2-), Mg~(2+), and Hadacidin [J] . Bradley W. Poland, Shy-Fuh Lee, Mani V. Subramanian, Biochemistry . 1996,第49期

机译：大肠杆菌腺苷琥珀酸合成酶的精制晶体结构，与羟基龙胆素5'-磷酸盐，GDP，HPO_4〜（2-），Mg〜（2+）和哈达丁复合
2. ADENYLOSUCCINATE SYNTHETASE - SITE OF ACTION OF HYDANTOCIDIN, A MICROBIAL PHYTOTOXIN [J] . Siehl DL., Walters EW., Lee SF., Plant physiology . 1996,第3期

机译：腺苷酸合成酶-微生物毒素-扁豆素的作用部位
3. Exquisite Modulation of the Active Site of Methanocaldococcus jannaschii Adenylosuccinate Synthetase in Forward Reaction Complexes [J] . Karnawat Vishakha, Mehrotra Sonali, Balaram Hemalatha, Biochemistry . 2016,第17期

机译：精细调节正向反应复合物中詹氏甲烷球菌腺苷琥珀酸合成酶的活性位点
4. Predicting target-ligand interactions using protein ligand-binding site and ligand substructures [C] . Caihua Wang, Juan Liu, Fei Luo, Asia-Pacific Bioinformatics Conference . 2015

机译：使用蛋白质配体结合位点和配体亚结构预测靶 - 配体相互作用
5. Molecular interactions of adipocyte fatty acid-binding protein with activating and non-activating ligands: Protein oligomerization and ligand binding sites [D] . Rizk, Samar Helmy. 2013

机译：脂肪细胞脂肪酸结合蛋白与活化和非活化配体的分子相互作用：蛋白质低聚和配体结合位点
6. The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase. [O] . R Fonné-Pfister, P Chemla, E Ward, 1996

机译：与目标结合的除草剂的作用方式和结构：活化的hydantocidin与腺苷琥珀酸合成酶的反馈调节位点的结合。
7. The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase. [O] . Fonné-Pfister, R, Chemla, P, Ward, E, 1996

机译：与目标结合的除草剂的作用方式和结构：活化的hydantocidin与腺苷琥珀酸合成酶的反馈调节位点的结合。

The mode of action and the structure of a herbicide in complex with its target: Binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase

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