Effects of inefficient cleavage of the signal sequence of HIV-1 gp120 on its association with calnexin, folding, and intracellular transport

Yan Li; John J. M. Bergeron; Lizhong Luo

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Effects of inefficient cleavage of the signal sequence of HIV-1 gp120 on its association with calnexin, folding, and intracellular transport

机译：HIV-1 gp120信号序列的低效切割对其与钙结合蛋白，折叠和细胞内转运的关联的影响

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The HIV-1 envelope glycoprotein gp120 dis- plays inefficient intracellular transport, which is caused by its retention in the endoplasmic reticulum. Coexpression in insect cells (Sf9) of HIV-1 gp120 with calnexin has shown that their interaction was modulated by the signal sequence of HIV-1 gp120. gp120, with its natural signal sequence, showed a pro- longed association with calnexin with a t1/2 of greater than 20 min. Replacement of the natural signal sequence with the signal sequence from mellitin led to a decreased time of association of gp120 with calnexin (t1/2 <10 min).

机译：HIV-1包膜糖蛋白gp120的胞内转运效率低下，这是由于其保留在内质网中。 HIV-1 gp120在昆虫细胞（Sf9）中与钙结合蛋白的共表达表明，它们的相互作用受HIV-1 gp120的信号序列调节。具有自然信号序列的gp120与钙粘蛋白的结合时间延长，t1 / 2大于20分钟。将天然信号序列替换为来自mellitin的信号序列，从而缩短了gp120与钙粘蛋白的缔合时间（t1 / 2 <10分钟）。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9606-9611|共6页
作者
Yan Li; John J. M. Bergeron; Lizhong Luo;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. The HIV-1 Env protein signal sequence retards its cleavage and down-regulates the glycoprotein folding. [J] . Li Y, Luo L, Thomas DY, Virology . 2000,第2期

机译：HIV-1 Env蛋白信号序列可延缓其裂解并下调糖蛋白折叠。
2. The effect of the membrane-proximal tyrosine-based sorting signal of HIV-1 gp41 on viral infectivity depends on sequences within gp120 [J] . Day JR, Van Damme N, Guatelli JC Virology . 2006,第2期

机译：HIV-1 gp41的基于膜近酪氨酸的分选信号对病毒感染性的影响取决于gp120中的序列
3. Effect of promoters and signal sequences on the production of secreted HIV-1 gp120 protein in the baculovirus system [J] . Golden A., van Schravendijk MR., Sullivan BJ., Protein Expression and Purification . 1998,第1期

机译：启动子和信号序列对杆状病毒系统中分泌的HIV-1 gp120蛋白产生的影响
4. Synthesis of a covalently reactive antigen analog derived from a conserved sequence of HIV-1 gp120 [C] . Hiroaki Taguchi, Yasuhiro Nishiyama, Gary S.Burr, the International Peptide Symposium . 2001

机译：合成HIV-1 GP120保守序列的共价反应性抗原模拟
5. Sequence-based genotyping of killer cell immunoglobulin-like receptors and their associations with HIV-1 resistance and disease progression. [D] . Hardie, Rae-Anne Michelle. 2009

机译：杀伤细胞免疫球蛋白样受体的基于序列的基因分型及其与HIV-1耐药性和疾病进展的关系。
6. Effects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin folding and intracellular transport. [O] . Y Li, J J Bergeron, L Luo, 1996

机译：HIV-1 gp 120信号序列的低效切割对其与钙结合蛋白折叠和细胞内转运的关联的影响。
7. Effects of inefficient cleavage of the signal sequence of HIV-1 gp 120 on its association with calnexin, folding, and intracellular transport. [O] . Li, Y, Bergeron, J J, Luo, L, 1996

机译：HIV-1 gp 120信号序列的低效切割对其与钙结合蛋白，折叠和细胞内转运的关联的影响。
8. No T-Cell Tyrosine Protein Kinase Signalling or Calcium Mobilization after CD4Association with HIV-1 or HIV-1 gp120 [R] . Horak, I. D., Popovic, M., Horak, E. M., 1990

机译：CD4与HIV-1或HIV-1 gp120结合后没有T细胞酪氨酸蛋白激酶信号或钙动员

Effects of inefficient cleavage of the signal sequence of HIV-1 gp120 on its association with calnexin, folding, and intracellular transport

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