The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain

Kerstin Schuddekopf; Michael Schorpp; Thomas Boehm

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The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain

机译：裸基因座编码的whn转录因子包含一个进化保守的和功能上必不可少的激活域

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Mutations in the whn gene are associated with the phenotype of congenital athymia and hairlessness in mouse and rat. The whn gene encodes a presumptive tran- scription factor with a DNA binding domain of the forkhead/ winged-helix class. Two previously described null alleles en- code truncated whn proteins lacking the characteristic DNA binding domain. In the rat rnu allele described here, a nonsense mutation in exon 8 of the when gene was identified.

机译：whn基因的突变与小鼠和大鼠中先天性无胸腺的表型和无毛有关。 whn基因编码一个假定的转录因子，具有叉头/有翼螺旋类的DNA结合结构域。先前描述的两个无效等位基因编码缺少特征性DNA结合域的截短的whn蛋白。在此处描述的大鼠rnu等位基因中，鉴定了when基因的外显子8中的无意义突变。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9661-9664|共4页
作者
Kerstin Schuddekopf; Michael Schorpp; Thomas Boehm;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. A highly conserved domain of RNA polymerase II shares a functional element with acidic activation domains of upstream transcription factors. [J] . H Xiao, J D Friesen, J T Lis Molecular and Cellular Biology . 1994,第11期

机译：RNA聚合酶II的高度保守的结构域与上游转录因子的酸性激活结构域共享功能元件。
2. Functional and conserved domains of the Drosophila transcription factor encoded by the segmentation gene knirps. [J] . N Gerwin, A La Rosée, F Sauer, Molecular and Cellular Biology . 1994,第12期

机译：果蝇转录因子的功能和保守结构域由分割基因knirps编码。
3. A Drosophila winged-helix nude (whn)-like transcription factor with essential functions throughout development [J] . Isamu Sugimura, Tadashi Adachi-Yamada, Yoshimi Nishi, Development Growth and Differentiation . 2000,第3期

机译：一种果蝇翅膀螺旋裸（WHN） - 在整个发育中具有基本功能的转录因子
4. Isolation and characterization of novel transcription factors EREBPs containing conserved EREBP/AP2 domain in Triticum aestivum. [C] . Z. S. Xu, Y. Z. Ma, X. G. Cheng, International Wheat Genetics Symposium . 2003

机译：小鼠含有保守的eREBP / AP2结构域的新型转录因子Erebps的分离与表征。
5. Characterization of the Arabidopsis thaliana CBF1 transcription factor: Functional role of two evolutionarily conserved signature sequences. [D] . Canella, Donatella. 2007

机译：拟南芥CBF1转录因子的表征：两个进化保守的签名序列的功能作用。
6. The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain. [O] . K Schüddekopf, M Schorpp, T Boehm 1996

机译：裸基因座编码的whn转录因子包含一个进化保守的和功能上必不可少的激活域。
7. The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain. [O] . Schüddekopf, K, Schorpp, M, Boehm, T 1996

机译：裸基因座编码的whn转录因子包含一个进化保守的和功能上必不可少的激活域。

The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain

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