Presence of mRNA for glutamic acid decarboxylase in both excitatory and inhibitory neurons

Yanxiang Cao; Karen S. Wilcox; Claudia E. Martin

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Presence of mRNA for glutamic acid decarboxylase in both excitatory and inhibitory neurons

机译：兴奋性和抑制性神经元中谷氨酸脱羧酶的mRNA的存在

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摘要

Neurons in very low density hippocampal cultures that are physiologically identified as either GABAer- gic inhibitory or glutamatergic excitatory all contain mRNA for the γ-aminobutyric acid (GABA) synthetic enzyme, glu- tamic acid decarboxylase (GAD), as detected by single cell mRNA amplification and PCR. However, consistent with the physiology, immunocytochemistry revealed that only a subset of the neurons stain for either GAD protein or GABA.

机译：通过单细胞mRNA检测，在生理学上被鉴定为GABA抑制性或谷氨酸能兴奋性的极低密度海马培养物中的神经元均含有γ-氨基丁酸（GABA）合成酶，谷氨酸脱羧酶（GAD）的mRNA。扩增和PCR。然而，与生理学一致，免疫细胞化学显示只有一部分神经元对GAD蛋白或GABA染色。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9844-9849|共6页
作者
Yanxiang Cao; Karen S. Wilcox; Claudia E. Martin;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Distribution of glycine transporter 2 mRNA-containing neurons in relation to glutamic acid decarboxylase mRNA-containing neurons in rat medulla. [J] . Tanaka I, Ezure K, Kondo M Neuroscience Research: The Official Journal of the Japan Neuroscience Society . 2003,第2期

机译：大鼠延髓中含甘氨酸转运蛋白2 mRNA的神经元与含谷氨酸脱羧酶mRNA的神经元的分布。
2. Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6-hydroxydopamine lesion. [J] . Yamamoto N, Soghomonian JJ Neuroscience: An International Journal under the Editorial Direction of IBRO . 2008,第3期

机译：在单侧6-侧成年大鼠中，SKF-81297诱导的纹状体黑质神经元中谷氨酸脱羧酶65和67 mRNA水平的增加以及黑质（pars reticulata）黑质中GABA（A）受体α1亚基mRNA水平的降低。羟多巴胺病变。
3. Effects of brain-derived neurotrophic factor and neurotrophin-3 on expression of mRNAs encoding c-Fos, neuropeptides and glutamic acid decarboxylase in cultured spinal neurons. [J] . Kim HS, Lee SJ, Kim DS, Neuroreport . 2000,第17期

机译：脑源性神经营养因子和Neurotrophin-3对培养的脊髓神经元中编码c-Fos，神经肽和谷氨酸脱羧酶的mRNA表达的影响。
4. Development of Artificial Glutamic Acid Decarboxylase ~Benchmark Analysisof Native and Artificial Enzymes Generated by a Sequence-Based DesignMethod with or without Phylogenetic Data~ [C] . Hiroshi Takagi, Kohei Kozuka, Kenta Mimura 日本化学会春季年会 . 2020

机译：一种人工谷氨酸脱羧酶〜基于序列的设计方法产生的天然和人工酶的基准分析〜
5. The influence of neural activity on the regulation of glutamic acid decarboxylase activity andmRNA levels in the cerebellum. [D] . Litwak, Joseph Martin. 1991

机译：神经活动对小脑谷氨酸脱羧酶活性和mRNA水平调节的影响。
6. Presence of mRNA for glutamic acid decarboxylase in both excitatory and inhibitory neurons. [O] . Y Cao, K S Wilcox, C E Martin, 1996

机译：兴奋性和抑制性神经元均存在谷氨酸脱羧酶的mRNA。
7. Presence of mRNA for glutamic acid decarboxylase in both excitatory and inhibitory neurons. [O] . Cao, Y, Wilcox, K S, Martin, C E, 1996

机译：兴奋性和抑制性神经元均存在谷氨酸脱羧酶的mRNA。
8. Inhibition of Glutamic Acid Decarboxylase and gamma-Aminobutyric Acid Transaminase by Sodium Cyanide. [R] . Cassel, G., Karlsson, L., Sellstroem, A. 1991

机译：用氰化钠抑制谷氨酸脱羧酶和γ-氨基丁酸转氨酶。

Presence of mRNA for glutamic acid decarboxylase in both excitatory and inhibitory neurons

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