TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling

Takaomi Ishida; Tadashi Tojo; Tsutomu Aoki

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TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling

机译：TRAF5，一种新型的肿瘤坏死因子受体相关因子家族蛋白，介导CD40信号传导

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Signals emanating from CD40 play crucial roles in B-cell function. To identify molecules that transduce CD40 signalings, we have used the yeast two-hybrid system to clone cDNAs encoding proteins that bind the cytoplasmic tail of CD40. A cDNA encoding a putative signal transducer protein, designated TRAF5, has been molecularly cloned. TRAF5 has a tumor necrosis factor receptor-associated factor (TRAF) domain in its carboxyl terminus and is most homol- ogous to TRAF3, also known as CRAF1, CD40bp, or LAP-1, a previously identified CD40-associated factor.

机译：CD40发出的信号在B细胞功能中起关键作用。为了鉴定可转导CD40信号的分子，我们使用了酵母双杂交系统克隆了编码与CD40胞质尾结合的蛋白质的cDNA。编码假定信号转导蛋白的cDNA（称为TRAF5）已被分子克隆。 TRAF5的羧基末端具有肿瘤坏死因子受体相关因子（TRAF）结构域，与TRAF3最相似，也称为CRAF1，CD40bp或LAP-1（先前已确定的CD40相关因子）。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1996年第18期|p.9437-9442|共6页
作者
Takaomi Ishida; Tadashi Tojo; Tsutomu Aoki;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein kinase signaling pathways. [J] . Pearson LL, Castle BE, Kehry MR International immunology. . 2001,第3期

机译：CD40介导的单核细胞信号转导：肿瘤坏死因子受体相关因子mRNA的上调和丝裂原激活的蛋白激酶信号转导途径的激活。
2. Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway. [J] . Yacoub D, Hachem A, Theoret JF, Arteriosclerosis, thrombosis, and vascular biology . 2010,第12期

机译：可溶性CD40配体的水平升高会通过CD40依赖性肿瘤坏死因子受体相关因子2 / Rac1 / p38丝裂原激活的蛋白激酶信号传导途径加剧血小板聚集和血栓形成。
3. CD40-Tumor necrosis factor receptor-associated factor (TRAF) interactions: Regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization [J] . Pullen SS., Everdeen DS., Dang TTA., Biochemistry . 1998,第34期

机译：CD40-肿瘤坏死因子受体相关因子（TRAF）相互作用：通过多个TRAF结合位点和TRAF异源寡聚化调节CD40信号传导。
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机译：p38丝裂原活化蛋白激酶介导肿瘤坏死因子α信号在成纤维样滑膜细胞中的基因组靶点。
6. TRAF5 a novel tumor necrosis factor receptor-associated factor family protein mediates CD40 signaling. [O] . T K Ishida, T Tojo, T Aoki, 1996

机译：TRAF5一种新型的肿瘤坏死因子受体相关因子家族蛋白介导CD40信号传导。
7. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. [O] . Ishida, T K, Tojo, T, Aoki, T, 1996

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8. Hantaan Virus Nucleocapsid Protein Binds to Importin alpha Proteins and Inhibits Tumor Necrosis Factor Alpha-Induced Activation of Nuclear Factor Kappa B [R] . Taylor, S. L., Frias-Staheli, N., Garcia-Sastre, A., 2008

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TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling

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